biostudies-literatureSargent JDNIDA NIH HHSU.S. Department of Health and Human ServicesNational Institutes of HealthCenter for Tobacco Products, Food and Drug AdministrationNational Institute on Drug AbuseNIH HHS1607-1618https://www.ebi.ac.uk/biostudies/studies/S-EPMC9575972biostudies-literatureUnknown24(10)<h4>Introduction</h4>We examined the relationship between current tobacco use and functionally important respiratory symptoms.<h4>Methods</h4>Longitudinal cohort study of 16 295 US adults without COPD in Waves 2-3 (W2-3, 2014-2016) of the Population Assessment of Tobacco and Health Study. Exposure-Ten mutually exclusive categories of tobacco use including single product, multiple product, former, and never use (reference). Outcome-Seven questions assessing wheezing/cough were summed to create a respiratory symptom index; cutoffs of ≥2 and ≥3 were associated with functional limitations and poorer health. Multivariable regressions examined both cutoffs cross-sectionally and change over approximately 12 months, adjusting for confounders.<h4>Results</h4>All tobacco use categories featuring cigNicotine & tobacco research : official journal of the Society for Research on Nicotine and TobaccoTobacco Use and Respiratory Symptoms Among Adults: Findings From the Longitudinal Population Assessment of Tobacco and Health (PATH) Study 2014-2016.PMC9575972HHSN271201100027CHyland ALiu JBorek NPierce JPAnic GNiaura RTaylor KABrunette MSchwartz LEdwards KCCummings KMThekkudan TKimmel HLSargent JDGardner LDWoloshin SGoniewicz MLCallahan-Lyon PTanski SHalenar MJEmond JChen YfalseTobacco Use and Respiratory Symptoms Among Adults: Findings From the Longitudinal Population Assessment of Tobacco and Health (PATH) Study 2014-2016.<h4>Introduction</h4>We examined the relationship between current tobacco use and functionally important respiratory symptoms.<h4>Methods</h4>Longitudinal cohort study of 16 295 US adults without COPD in Waves 2-3 (W2-3, 2014-2016) of the Population Assessment of Tobacco and Health Study. Exposure-Ten mutually exclusive categories of tobacco use including single product, multiple product, former, and never use (reference). Outcome-Seven questions assessing wheezing/cough were summed to create a respiratory symptom index; cutoffs of ≥2 and ≥3 were associated with functional limitations and poorer health. Multivariable regressions examined both cutoffs cross-sectionally and change over approximately 12 months, adjusting for confounders.<h4>Results</h4>All tobacco use categories featuring cig2022-01-01T00:00:00Z2022 Oct2025-04-04T07:26:49.431Z2025-04-04T07:26:49.431ZS-EPMC95759723536632210.1093/ntr/ntac080