{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["18(15)"],"submitter":["Huang L"],"pubmed_abstract":["The small intestine is main site of exogenous lipid digestion and absorption, and it is important for lipid metabolic homeostasis. Cell death-inducing DNA fragmentation-factor like effector C (CIDEC) is active in lipid metabolism in tissues other than those in the intestine. We developed small intestine-specific CIDEC (SI-CIDEC<sup>-/-</sup>) knockout C57BL/6J mice by Cre/LoxP recombination to investigate the <i>in vivo</i> effects of intestinal CIDEC on lipid metabolism. Eight-week-old SI-CIDEC<sup>-/-</sup> mice fed a high-fat diet for 14 weeks had 15% lower body weight, 30% less body fat mass, and 79% lower liver triglycerides (TG) than wild-type (WT) mice. In addition, hepatic steatosis and fatty liver inflammation were less severe in knockout mice fed a high-fat diet (HFD) compared wi"],"journal":["International journal of biological sciences"],"pagination":["5740-5752"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9576510"],"repository":["biostudies-literature"],"pubmed_title":["Small Intestine-specific Knockout of CIDEC Improves Obesity and Hepatic Steatosis by Inhibiting Synthesis of Phosphatidic Acid."],"pmcid":["PMC9576510"],"pubmed_authors":["Zhou L","Li Y","Yang Y","Pan T","Xiao L","Xiao Y","Liao Q","Huang L","Liu S","Aluo Z","Yu J","Sun Y"],"additional_accession":[]},"is_claimable":false,"name":"Small Intestine-specific Knockout of CIDEC Improves Obesity and Hepatic Steatosis by Inhibiting Synthesis of Phosphatidic Acid.","description":"The small intestine is main site of exogenous lipid digestion and absorption, and it is important for lipid metabolic homeostasis. Cell death-inducing DNA fragmentation-factor like effector C (CIDEC) is active in lipid metabolism in tissues other than those in the intestine. We developed small intestine-specific CIDEC (SI-CIDEC<sup>-/-</sup>) knockout C57BL/6J mice by Cre/LoxP recombination to investigate the <i>in vivo</i> effects of intestinal CIDEC on lipid metabolism. Eight-week-old SI-CIDEC<sup>-/-</sup> mice fed a high-fat diet for 14 weeks had 15% lower body weight, 30% less body fat mass, and 79% lower liver triglycerides (TG) than wild-type (WT) mice. In addition, hepatic steatosis and fatty liver inflammation were less severe in knockout mice fed a high-fat diet (HFD) compared wi","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-05-29T22:25:29.709Z","creation":"2025-02-19T03:02:09.607Z"},"accession":"S-EPMC9576510","cross_references":{"pubmed":["36263170"],"doi":["10.7150/ijbs.74348"]}}