biostudies-literatureUnknown18(15)Huang LThe small intestine is main site of exogenous lipid digestion and absorption, and it is important for lipid metabolic homeostasis. Cell death-inducing DNA fragmentation-factor like effector C (CIDEC) is active in lipid metabolism in tissues other than those in the intestine. We developed small intestine-specific CIDEC (SI-CIDEC^-/-) knockout C57BL/6J mice by Cre/LoxP recombination to investigate the <i>in vivo</i> effects of intestinal CIDEC on lipid metabolism. Eight-week-old SI-CIDEC^-/- mice fed a high-fat diet for 14 weeks had 15% lower body weight, 30% less body fat mass, and 79% lower liver triglycerides (TG) than wild-type (WT) mice. In addition, hepatic steatosis and fatty liver inflammation were less severe in knockout mice fed a high-fat diet (HFD) compared wiInternational journal of biological sciences5740-5752https://www.ebi.ac.uk/biostudies/studies/S-EPMC9576510biostudies-literatureSmall Intestine-specific Knockout of CIDEC Improves Obesity and Hepatic Steatosis by Inhibiting Synthesis of Phosphatidic Acid.PMC9576510Zhou LLi YYang YPan TXiao LXiao YLiao QHuang LLiu SAluo ZYu JSun YfalseSmall Intestine-specific Knockout of CIDEC Improves Obesity and Hepatic Steatosis by Inhibiting Synthesis of Phosphatidic Acid.The small intestine is main site of exogenous lipid digestion and absorption, and it is important for lipid metabolic homeostasis. Cell death-inducing DNA fragmentation-factor like effector C (CIDEC) is active in lipid metabolism in tissues other than those in the intestine. We developed small intestine-specific CIDEC (SI-CIDEC^-/-) knockout C57BL/6J mice by Cre/LoxP recombination to investigate the <i>in vivo</i> effects of intestinal CIDEC on lipid metabolism. Eight-week-old SI-CIDEC^-/- mice fed a high-fat diet for 14 weeks had 15% lower body weight, 30% less body fat mass, and 79% lower liver triglycerides (TG) than wild-type (WT) mice. In addition, hepatic steatosis and fatty liver inflammation were less severe in knockout mice fed a high-fat diet (HFD) compared wi2022-01-01T00:00:00Z20222026-05-29T22:25:29.709Z2025-02-19T03:02:09.607ZS-EPMC95765103626317010.7150/ijbs.74348