{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["4(11)"],"submitter":["Overi D"],"pubmed_abstract":["<h4>Background & aims</h4>Primary biliary cholangitis (PBC) is a chronic cholangiopathy characterised by immuno-mediated injury of interlobular bile ducts leading to intrahepatic cholestasis and progressive liver fibrosis. PBC histology is characterised by portal inflammation, progressive fibrosis, ductopenia, and the appearance of the so-called ductular reaction. The aim of the present study was to investigate the pathogenetic relevance of ductular reaction in PBC.<h4>Methods</h4>Liver biopsies were collected from naïve people with PBC (N = 87). Clinical-serological parameters were obtained at diagnosis and after 1 year of ursodeoxycholic acid (UDCA) treatment. Histological staging was performed on all slides according to multiple scoring systems and criteria for PBC. Liver samples were o"],"journal":["JHEP reports : innovation in hepatology"],"pagination":["100556"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9576897"],"repository":["biostudies-literature"],"pubmed_title":["Role of ductular reaction and ductular-canalicular junctions in identifying severe primary biliary cholangitis."],"pmcid":["PMC9576897"],"pubmed_authors":["Gerussi A","Floreani A","Alpini G","Alvaro D","Rigamonti C","Onori P","Kennedy L","Glaser S","Carbone M","D'Amato D","Zucchini N","Carpino G","Francis H","Cardinale V","Cristoferi L","Overi D","Invernizzi P","Vigano M","Gaudio E","Venere R"],"additional_accession":[]},"is_claimable":false,"name":"Role of ductular reaction and ductular-canalicular junctions in identifying severe primary biliary cholangitis.","description":"<h4>Background & aims</h4>Primary biliary cholangitis (PBC) is a chronic cholangiopathy characterised by immuno-mediated injury of interlobular bile ducts leading to intrahepatic cholestasis and progressive liver fibrosis. PBC histology is characterised by portal inflammation, progressive fibrosis, ductopenia, and the appearance of the so-called ductular reaction. The aim of the present study was to investigate the pathogenetic relevance of ductular reaction in PBC.<h4>Methods</h4>Liver biopsies were collected from naïve people with PBC (N = 87). Clinical-serological parameters were obtained at diagnosis and after 1 year of ursodeoxycholic acid (UDCA) treatment. Histological staging was performed on all slides according to multiple scoring systems and criteria for PBC. Liver samples were o","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-04-19T21:18:24.573Z","creation":"2025-04-19T21:18:24.573Z"},"accession":"S-EPMC9576897","cross_references":{"pubmed":["36267871"],"doi":["10.1016/j.jhepr.2022.100556"]}}