biostudies-literatureUnknown4(11)Overi D<h4>Background & aims</h4>Primary biliary cholangitis (PBC) is a chronic cholangiopathy characterised by immuno-mediated injury of interlobular bile ducts leading to intrahepatic cholestasis and progressive liver fibrosis. PBC histology is characterised by portal inflammation, progressive fibrosis, ductopenia, and the appearance of the so-called ductular reaction. The aim of the present study was to investigate the pathogenetic relevance of ductular reaction in PBC.<h4>Methods</h4>Liver biopsies were collected from naïve people with PBC (N = 87). Clinical-serological parameters were obtained at diagnosis and after 1 year of ursodeoxycholic acid (UDCA) treatment. Histological staging was performed on all slides according to multiple scoring systems and criteria for PBC. Liver samples were oJHEP reports : innovation in hepatology100556https://www.ebi.ac.uk/biostudies/studies/S-EPMC9576897biostudies-literatureRole of ductular reaction and ductular-canalicular junctions in identifying severe primary biliary cholangitis.PMC9576897Gerussi AFloreani AAlpini GAlvaro DRigamonti COnori PKennedy LGlaser SCarbone MD'Amato DZucchini NCarpino GFrancis HCardinale VCristoferi LOveri DInvernizzi PVigano MGaudio EVenere RfalseRole of ductular reaction and ductular-canalicular junctions in identifying severe primary biliary cholangitis.<h4>Background & aims</h4>Primary biliary cholangitis (PBC) is a chronic cholangiopathy characterised by immuno-mediated injury of interlobular bile ducts leading to intrahepatic cholestasis and progressive liver fibrosis. PBC histology is characterised by portal inflammation, progressive fibrosis, ductopenia, and the appearance of the so-called ductular reaction. The aim of the present study was to investigate the pathogenetic relevance of ductular reaction in PBC.<h4>Methods</h4>Liver biopsies were collected from naïve people with PBC (N = 87). Clinical-serological parameters were obtained at diagnosis and after 1 year of ursodeoxycholic acid (UDCA) treatment. Histological staging was performed on all slides according to multiple scoring systems and criteria for PBC. Liver samples were o2022-01-01T00:00:00Z2022 Nov2025-04-19T21:18:24.573Z2025-04-19T21:18:24.573ZS-EPMC95768973626787110.1016/j.jhepr.2022.100556