biostudies-literatureSeo MKorean Society of Neurogastroenterology and MotilityMinistry of Science and ICT, South KoreaNational Research Foundation of Korea608-617https://www.ebi.ac.uk/biostudies/studies/S-EPMC9577571biostudies-literatureUnknown28(4)<h4>Background/aims</h4>Biofeedback therapy is widely used to treat patients with chronic constipation, especially those with dyssynergic defecation. Yet, the utility of high-resolution manometry with novel parameters in the prediction of biofeedback response has not been reported. Thus, we constructed a model for predicting biofeedback therapy responders by applying the concept of integrated pressurized volume in patients undergoing high-resolution anorectal manometry.<h4>Methods</h4>Seventy-one female patients (age: 48-68 years) with dyssynergic defecation who underwent initial high-resolution anorectal manometry and subsequent biofeedback therapy were enrolled. The manometry profiles were used to calculate the 3-dimensional integrated pressurized volumes by multiplying the distance, timJournal of neurogastroenterology and motilityPredicting Responsiveness to Biofeedback Therapy Using High-resolution Anorectal Manometry With Integrated Pressurized Volume.PMC9577571NRF-2021R1G1A100831KSNM-12-012KSNM-20-02Noh WYe BDHwang SWMyung SJChoi KMLee JSeo MSeo SYYang DHYoon IJYoon JKim DYJung KWYang SKJoo SLee HJPark SHByeon JSfalsePredicting Responsiveness to Biofeedback Therapy Using High-resolution Anorectal Manometry With Integrated Pressurized Volume.<h4>Background/aims</h4>Biofeedback therapy is widely used to treat patients with chronic constipation, especially those with dyssynergic defecation. Yet, the utility of high-resolution manometry with novel parameters in the prediction of biofeedback response has not been reported. Thus, we constructed a model for predicting biofeedback therapy responders by applying the concept of integrated pressurized volume in patients undergoing high-resolution anorectal manometry.<h4>Methods</h4>Seventy-one female patients (age: 48-68 years) with dyssynergic defecation who underwent initial high-resolution anorectal manometry and subsequent biofeedback therapy were enrolled. The manometry profiles were used to calculate the 3-dimensional integrated pressurized volumes by multiplying the distance, tim2022-01-01T00:00:00Z2022 Oct2025-05-18T11:39:25.673Z2025-04-05T11:39:54.103ZS-EPMC95775713625036810.5056/jnm21137