biostudies-literatureUnknown10(18)Nie Q<h4>Background</h4>Methamphetamine (MA) abuse is a major global public health problem. However, it is not yet known whether cannabidiol (CBD) has protective effects on MA-induced cardiotoxicity. The present study investigated whether CBD has protective effects on MA-induced cardiac damage in rats via the protein kinase A/cyclic adenosine monophosphate (cAMP)-response element-binding protein (PKA/CREB) pathway.<h4>Methods</h4>A total of 30 rats were randomly divided into 5 groups. The rats were administered MA (10 mg/kg) by intraperitoneal (IP) injection once a day for 4 weeks, and with CBD (40 or 80 mg/kg, IP) treatment 1 h before the MA injections. Morphological changes were determined using hematoxylin and eosin and Masson's trichrome staining. The serum levels of interleukin (IL)-6 and Annals of translational medicine985https://www.ebi.ac.uk/biostudies/studies/S-EPMC9577756biostudies-literatureCannabidiol attenuates methamphetamine-induced cardiac inflammatory response through the PKA/CREB pathway in rats.PMC9577756Yang GPeng YDong WNie QShen BZhang RLi LYu HYu YHong SfalseCannabidiol attenuates methamphetamine-induced cardiac inflammatory response through the PKA/CREB pathway in rats.<h4>Background</h4>Methamphetamine (MA) abuse is a major global public health problem. However, it is not yet known whether cannabidiol (CBD) has protective effects on MA-induced cardiotoxicity. The present study investigated whether CBD has protective effects on MA-induced cardiac damage in rats via the protein kinase A/cyclic adenosine monophosphate (cAMP)-response element-binding protein (PKA/CREB) pathway.<h4>Methods</h4>A total of 30 rats were randomly divided into 5 groups. The rats were administered MA (10 mg/kg) by intraperitoneal (IP) injection once a day for 4 weeks, and with CBD (40 or 80 mg/kg, IP) treatment 1 h before the MA injections. Morphological changes were determined using hematoxylin and eosin and Masson's trichrome staining. The serum levels of interleukin (IL)-6 and 2022-01-01T00:00:00Z2022 Sep2025-04-19T21:18:50.341Z2025-04-19T21:18:50.341ZS-EPMC95777563626775310.21037/atm-22-4082