biostudies-literatureUnknown10(18)Meng L<h4>Background</h4>Dispersion of gray matter and white matter and abnormal hemodynamic changes are common in patients with chronic stenosis cerebral artery disease. It is not easy to capture these abnormal changes with conventional magnetic resonance imaging (MRI). Magnetic resonance spectroscopy (MRS) is useful for obtaining metabolic information in either preclinical or clinical applications. The aim of our study was to apply MRS to non-invasively investigate changes in brain metabolism in MRI-negative patients with chronic cerebral artery steno-occlusive disease.<h4>Methods</h4>We performed MRS examinations with 3.0T MRI on 34 patients with severe unilateral middle cerebral artery (MCA) stenosis or occlusion without parenchymal abnormalities. Additionally, N-acetylaspartic acid (NAA), cAnnals of translational medicine1003https://www.ebi.ac.uk/biostudies/studies/S-EPMC9577772biostudies-literatureThe pattern of brain metabolism in chronic steno-occlusive cerebral artery disease.PMC9577772Li HHuang ZMeng LfalseThe pattern of brain metabolism in chronic steno-occlusive cerebral artery disease.<h4>Background</h4>Dispersion of gray matter and white matter and abnormal hemodynamic changes are common in patients with chronic stenosis cerebral artery disease. It is not easy to capture these abnormal changes with conventional magnetic resonance imaging (MRI). Magnetic resonance spectroscopy (MRS) is useful for obtaining metabolic information in either preclinical or clinical applications. The aim of our study was to apply MRS to non-invasively investigate changes in brain metabolism in MRI-negative patients with chronic cerebral artery steno-occlusive disease.<h4>Methods</h4>We performed MRS examinations with 3.0T MRI on 34 patients with severe unilateral middle cerebral artery (MCA) stenosis or occlusion without parenchymal abnormalities. Additionally, N-acetylaspartic acid (NAA), c2022-01-01T00:00:00Z2022 Sep2025-04-19T21:18:33.5Z2025-04-19T21:18:33.5ZS-EPMC95777723626771610.21037/atm-22-3993