{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11(5)"],"submitter":["Cheng M"],"pubmed_abstract":["<h4>Background</h4>Somatostatin receptor (SSTR)-targeted positron emission tomography/computed tomography (PET/CT) imaging has risen to the forefront for neuroendocrine tumor (NET) detection and management, yet the variability of significant uptake variability (SUV) as a semiquantitative measure of disease detection and tumor response to treatment has not been fully explored.<h4>Methods</h4>We assess the reproducibility and interscan variability of SUV metrics of normal tissue and NET in serial <sup>68</sup>Ga-DOTA-NOC and <sup>68</sup>Ga-DOTA-TATE PET imaging to clinically monitor disease state. Eighty-one patients were enrolled in this retrospective study.<h4>Results</h4>Both primary and metastatic hepatic lesions demonstrated SUV (SUV<sub>mean</sub> 16.5±8.0). The median SUV<sub>mean</s"],"journal":["Hepatobiliary surgery and nutrition"],"pagination":["654-661"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9577978"],"repository":["biostudies-literature"],"pubmed_title":["Highly variable biodistribution of <sup>68</sup>Ga labeled somatostatin analogues <sup>68</sup>Ga-DOTA-NOC and <sup>68</sup>Ga-DOTA-TATE in neuroendocrine tumors: clinical implications for somatostatin receptor directed PET/CT."],"pmcid":["PMC9577978"],"pubmed_authors":["Cheng M","Tann M"],"additional_accession":[]},"is_claimable":false,"name":"Highly variable biodistribution of <sup>68</sup>Ga labeled somatostatin analogues <sup>68</sup>Ga-DOTA-NOC and <sup>68</sup>Ga-DOTA-TATE in neuroendocrine tumors: clinical implications for somatostatin receptor directed PET/CT.","description":"<h4>Background</h4>Somatostatin receptor (SSTR)-targeted positron emission tomography/computed tomography (PET/CT) imaging has risen to the forefront for neuroendocrine tumor (NET) detection and management, yet the variability of significant uptake variability (SUV) as a semiquantitative measure of disease detection and tumor response to treatment has not been fully explored.<h4>Methods</h4>We assess the reproducibility and interscan variability of SUV metrics of normal tissue and NET in serial <sup>68</sup>Ga-DOTA-NOC and <sup>68</sup>Ga-DOTA-TATE PET imaging to clinically monitor disease state. Eighty-one patients were enrolled in this retrospective study.<h4>Results</h4>Both primary and metastatic hepatic lesions demonstrated SUV (SUV<sub>mean</sub> 16.5±8.0). The median SUV<sub>mean</s","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-04-18T22:14:40.709Z","creation":"2025-04-07T10:03:31.755Z"},"accession":"S-EPMC9577978","cross_references":{"pubmed":["36268247"],"doi":["10.21037/hbsn-21-554"]}}