biostudies-literatureUnknown11(5)Cheng M<h4>Background</h4>Somatostatin receptor (SSTR)-targeted positron emission tomography/computed tomography (PET/CT) imaging has risen to the forefront for neuroendocrine tumor (NET) detection and management, yet the variability of significant uptake variability (SUV) as a semiquantitative measure of disease detection and tumor response to treatment has not been fully explored.<h4>Methods</h4>We assess the reproducibility and interscan variability of SUV metrics of normal tissue and NET in serial ⁶⁸Ga-DOTA-NOC and ⁶⁸Ga-DOTA-TATE PET imaging to clinically monitor disease state. Eighty-one patients were enrolled in this retrospective study.<h4>Results</h4>Both primary and metastatic hepatic lesions demonstrated SUV (SUV_mean 16.5±8.0). The median SUV<sub>mean</sHepatobiliary surgery and nutrition654-661https://www.ebi.ac.uk/biostudies/studies/S-EPMC9577978biostudies-literatureHighly variable biodistribution of ⁶⁸Ga labeled somatostatin analogues ⁶⁸Ga-DOTA-NOC and ⁶⁸Ga-DOTA-TATE in neuroendocrine tumors: clinical implications for somatostatin receptor directed PET/CT.PMC9577978Cheng MTann MfalseHighly variable biodistribution of ⁶⁸Ga labeled somatostatin analogues ⁶⁸Ga-DOTA-NOC and ⁶⁸Ga-DOTA-TATE in neuroendocrine tumors: clinical implications for somatostatin receptor directed PET/CT.<h4>Background</h4>Somatostatin receptor (SSTR)-targeted positron emission tomography/computed tomography (PET/CT) imaging has risen to the forefront for neuroendocrine tumor (NET) detection and management, yet the variability of significant uptake variability (SUV) as a semiquantitative measure of disease detection and tumor response to treatment has not been fully explored.<h4>Methods</h4>We assess the reproducibility and interscan variability of SUV metrics of normal tissue and NET in serial ⁶⁸Ga-DOTA-NOC and ⁶⁸Ga-DOTA-TATE PET imaging to clinically monitor disease state. Eighty-one patients were enrolled in this retrospective study.<h4>Results</h4>Both primary and metastatic hepatic lesions demonstrated SUV (SUV_mean 16.5±8.0). The median SUV<sub>mean</s2022-01-01T00:00:00Z2022 Oct2025-04-18T22:14:40.709Z2025-04-07T10:03:31.755ZS-EPMC95779783626824710.21037/hbsn-21-554