biostudies-literatureUnknown16Spagnuolo V<h4>Background</h4>Evidence regarding the impact of remdesivir (RDV) on SARS-CoV-2 viral clearance (VC) is scarce. The aim of this study was to compare VC timing in hospitalized COVID-19 patients who did or did not receive RDV.<h4>Methods</h4>This was a matched-cohort study of patients hospitalized with pneumonia, a SARS-CoV-2-positive nasopharyngeal swab (NPS) at admission, and at least one NPS during follow-up. Patients who received RDV (cases) and those who did not (controls) were matched in a 1:2 ratio by age, sex, and PaO₂/FiO₂ (P/F) values at admission. NPSs were analyzed using real-time polymerase chain reaction. Time to VC (within 30 days after hospital discharge) was estimated using the Kaplan-Meier curve. A multivariable Cox proportional hazard model was fitDrug design, development and therapy3645-3654https://www.ebi.ac.uk/biostudies/studies/S-EPMC9578770biostudies-literatureImpact of Remdesivir on SARS-CoV-2 Clearance in a Real-Life Setting: A Matched-Cohort Study.PMC9578770Racca SBruzzesi EDagna LTonelli MZangrillo AClementi NSpagnuolo VPoli AClementi MVoarino MCOVID-BioB Study GroupRovere Querini PCiceri FOltolini CTresoldi MCastagna AGalli LfalseImpact of Remdesivir on SARS-CoV-2 Clearance in a Real-Life Setting: A Matched-Cohort Study.<h4>Background</h4>Evidence regarding the impact of remdesivir (RDV) on SARS-CoV-2 viral clearance (VC) is scarce. The aim of this study was to compare VC timing in hospitalized COVID-19 patients who did or did not receive RDV.<h4>Methods</h4>This was a matched-cohort study of patients hospitalized with pneumonia, a SARS-CoV-2-positive nasopharyngeal swab (NPS) at admission, and at least one NPS during follow-up. Patients who received RDV (cases) and those who did not (controls) were matched in a 1:2 ratio by age, sex, and PaO₂/FiO₂ (P/F) values at admission. NPSs were analyzed using real-time polymerase chain reaction. Time to VC (within 30 days after hospital discharge) was estimated using the Kaplan-Meier curve. A multivariable Cox proportional hazard model was fit2022-01-01T00:00:00Z20222025-04-04T21:01:09.103Z2024-11-12T14:17:21.334ZS-EPMC95787703626852110.2147/DDDT.S369473