{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["47(1)"],"submitter":["Moreno G"],"pubmed_abstract":["<h4>Objective</h4>To determine if the use of corticosteroids was associated with Intensive Care Unit (ICU) mortality among whole population and pre-specified clinical phenotypes.<h4>Design</h4>A secondary analysis derived from multicenter, observational study.<h4>Setting</h4>Critical Care Units.<h4>Patients</h4>Adult critically ill patients with confirmed COVID-19 disease admitted to 63 ICUs in Spain.<h4>Interventions</h4>Corticosteroids vs. no corticosteroids.<h4>Main variables of interest</h4>Three phenotypes were derived by non-supervised clustering analysis from whole population and classified as (A: severe, B: critical and C: life-threatening). We performed a multivariate analysis after propensity optimal full matching (PS) for whole population and weighted Cox regression (HR) and Fin"],"journal":["Medicina intensiva"],"pagination":["23-33"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9579897"],"repository":["biostudies-literature"],"pubmed_title":["A differential therapeutic consideration for use of corticosteroids according to established COVID-19 clinical phenotypes in critically ill patients."],"pmcid":["PMC9579897"],"pubmed_authors":["Sancho Chinesta S","Vidal Cortes P","Bonell Goytisolo JM","Armestar F","Moreno G","Martin Serrano F","Sole-Violan J","Jorge Garcia R","Blasco Cortes M","Estella A","Nieto M","Sanchez Montori L","Rodriguez A","Vallverdu Perapoch I","Trefler S","Marin-Corral J","Ferrer R","Casamitjana Ortega AM","Hidalgo V","Gomez Alvarez J","on behalf COVID-19 SEMICYUC Working Group","Socias-Crespi L","Jimenez Herrera M","Marques Parra A","Murcia Paya J","Fraile Gutierrez V","Loza A","Ruiz-Botella M","Pozo Laderas JC","Bodi M","Forcelledo Espina L","deAlba-Aparicio M","Diaz E","Martin-Loeches I","Albaya-Moreno A"],"additional_accession":[]},"is_claimable":false,"name":"A differential therapeutic consideration for use of corticosteroids according to established COVID-19 clinical phenotypes in critically ill patients.","description":"<h4>Objective</h4>To determine if the use of corticosteroids was associated with Intensive Care Unit (ICU) mortality among whole population and pre-specified clinical phenotypes.<h4>Design</h4>A secondary analysis derived from multicenter, observational study.<h4>Setting</h4>Critical Care Units.<h4>Patients</h4>Adult critically ill patients with confirmed COVID-19 disease admitted to 63 ICUs in Spain.<h4>Interventions</h4>Corticosteroids vs. no corticosteroids.<h4>Main variables of interest</h4>Three phenotypes were derived by non-supervised clustering analysis from whole population and classified as (A: severe, B: critical and C: life-threatening). We performed a multivariate analysis after propensity optimal full matching (PS) for whole population and weighted Cox regression (HR) and Fin","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2026-05-28T05:51:04.321Z","creation":"2024-11-13T18:51:12.163Z"},"accession":"S-EPMC9579897","cross_references":{"pubmed":["36272908"],"doi":["10.1016/j.medine.2021.10.016"]}}