biostudies-literatureUnknown47(1)Moreno G<h4>Objective</h4>To determine if the use of corticosteroids was associated with Intensive Care Unit (ICU) mortality among whole population and pre-specified clinical phenotypes.<h4>Design</h4>A secondary analysis derived from multicenter, observational study.<h4>Setting</h4>Critical Care Units.<h4>Patients</h4>Adult critically ill patients with confirmed COVID-19 disease admitted to 63 ICUs in Spain.<h4>Interventions</h4>Corticosteroids vs. no corticosteroids.<h4>Main variables of interest</h4>Three phenotypes were derived by non-supervised clustering analysis from whole population and classified as (A: severe, B: critical and C: life-threatening). We performed a multivariate analysis after propensity optimal full matching (PS) for whole population and weighted Cox regression (HR) and FinMedicina intensiva23-33https://www.ebi.ac.uk/biostudies/studies/S-EPMC9579897biostudies-literatureA differential therapeutic consideration for use of corticosteroids according to established COVID-19 clinical phenotypes in critically ill patients.PMC9579897Sancho Chinesta SVidal Cortes PBonell Goytisolo JMArmestar FMoreno GMartin Serrano FSole-Violan JJorge Garcia RBlasco Cortes MEstella ANieto MSanchez Montori LRodriguez AVallverdu Perapoch ITrefler SMarin-Corral JFerrer RCasamitjana Ortega AMHidalgo VGomez Alvarez Jon behalf COVID-19 SEMICYUC Working GroupSocias-Crespi LJimenez Herrera MMarques Parra AMurcia Paya JFraile Gutierrez VLoza ARuiz-Botella MPozo Laderas JCBodi MForcelledo Espina LdeAlba-Aparicio MDiaz EMartin-Loeches IAlbaya-Moreno AfalseA differential therapeutic consideration for use of corticosteroids according to established COVID-19 clinical phenotypes in critically ill patients.<h4>Objective</h4>To determine if the use of corticosteroids was associated with Intensive Care Unit (ICU) mortality among whole population and pre-specified clinical phenotypes.<h4>Design</h4>A secondary analysis derived from multicenter, observational study.<h4>Setting</h4>Critical Care Units.<h4>Patients</h4>Adult critically ill patients with confirmed COVID-19 disease admitted to 63 ICUs in Spain.<h4>Interventions</h4>Corticosteroids vs. no corticosteroids.<h4>Main variables of interest</h4>Three phenotypes were derived by non-supervised clustering analysis from whole population and classified as (A: severe, B: critical and C: life-threatening). We performed a multivariate analysis after propensity optimal full matching (PS) for whole population and weighted Cox regression (HR) and Fin2023-01-01T00:00:00Z2023 Jan2026-05-28T05:51:04.321Z2024-11-13T18:51:12.163ZS-EPMC95798973627290810.1016/j.medine.2021.10.016