biostudies-literatureUnknown328(15)HEROES-RECOVER Network<h4>Importance</h4>Data on the epidemiology of mild to moderately severe COVID-19 are needed to inform public health guidance.<h4>Objective</h4>To evaluate associations between 2 or 3 doses of mRNA COVID-19 vaccine and attenuation of symptoms and viral RNA load across SARS-CoV-2 viral lineages.<h4>Design, setting, and participants</h4>A prospective cohort study of essential and frontline workers in Arizona, Florida, Minnesota, Oregon, Texas, and Utah with COVID-19 infection confirmed by reverse transcriptase-polymerase chain reaction testing and lineage classified by whole genome sequencing of specimens self-collected weekly and at COVID-19 illness symptom onset. This analysis was conducted among 1199 participants with SARS-CoV-2 from December 14, 2020, to April 19, 2022, with follow-up unJAMA1523-1533https://www.ebi.ac.uk/biostudies/studies/S-EPMC9579910biostudies-literatureAssociation of mRNA Vaccination With Clinical and Virologic Features of COVID-19 Among US Essential and Frontline Workers.PMC9579910MacNeil AGrijalva SWilliams JLittau SDouglas CTaylor GPatel RSettele NReyes RWoods EAllacher NBeeram MCalhoun NBourdelle BSolle NSCowling HDickerson MLundgren JGerber IBissonnette AReyes AFisher JRojas CEtolue JEllingson KStrong AShea MGoebert ECarson KWhiting HSouza AArroliga ATallman MMaughan GAlaspa JPoe BPCruz ANaleway ALBeitel SLangston MReed SMadan BRamadan FHendrix CWong DSowell JKrupp KStefanski EDolezilek JBruner MHall APick CStanford JGreen ALeClair LDeal CMeece JSlocum AMcGarry NTovar GKlinck CMurray SRespet KBrunner MSokol BBloodworth RGerald LFugal AHunt ALee IAAzziz-Baumgartner EThacker JEden ETyner HLBarnes JSharma PMistry PHunt DRSteffen LFlores JYoo YMMartinez MJones JFleary DEFowlkes ALMiiro FThiese MSFlangos AJones TMorris CStafki DIslam RArteaga AHornbrook MMinoughan MGaglani MScott JMao JPickett SNava RPerez CLuong KWebby RJHoffman EGomez VHoffman LJovel KVo JSmidt SPena MAnderson LMayhew NStucki MNikolich-Zugich JPorter CMevises KYoon SKPrado YBaccam NMakar JMurthy KNsengiyunva ACarrera OWilson MTsang FArlington IThompson MGConnor TStewart GHollister JDonald LCColeman AHerring MKZheng PEdwards LJHanson HKutty PThornburg NCapell SOdean MJBrown RTFabrizio TPBateman ASmith MEBedrick EJEarley KGuenther KLee MThomas JBigler SPatlan KZayed MTang NChatard KDawson DWheeler MThomas TSlaughter RSuarez NLamberte JMPerlman RReynolds SCox CBlack BNoriega RJatla MBaker JStinson PSchaefer CPhillips ALCarmona ATran KArvay MHegmann KTDesai MSWesley MGHadden LPraggastis JSapp DSGroom HCPrather KJones JTPowaukee TShang NWang RLowe AMorrill TCStubbs TNaff KButcher TGerald JKKhan SMBlais JJarrah MBurgess JLSchrag SPark KDuque JTestoff ASun XFeliciano PKendrick SGallimore-Wilson DMirabito JRomine JGraham TMayer JHealy OGrant LMak JJordin RHEROES-RECOVER NetworkPriest ELuzio CArani GHilyard ROlsho LEWPikowski CRivers PDunnigan KBialobok KRose STrejo IObrien KRobinson MYingst AHarder JCampbell RCaban-Martinez AJVerani JAstor BSmith MGaribaldi JSmith TStea DKuntz JLLobos ALutrick KEttlinger JJoseph GFry AfalseAssociation of mRNA Vaccination With Clinical and Virologic Features of COVID-19 Among US Essential and Frontline Workers.<h4>Importance</h4>Data on the epidemiology of mild to moderately severe COVID-19 are needed to inform public health guidance.<h4>Objective</h4>To evaluate associations between 2 or 3 doses of mRNA COVID-19 vaccine and attenuation of symptoms and viral RNA load across SARS-CoV-2 viral lineages.<h4>Design, setting, and participants</h4>A prospective cohort study of essential and frontline workers in Arizona, Florida, Minnesota, Oregon, Texas, and Utah with COVID-19 infection confirmed by reverse transcriptase-polymerase chain reaction testing and lineage classified by whole genome sequencing of specimens self-collected weekly and at COVID-19 illness symptom onset. This analysis was conducted among 1199 participants with SARS-CoV-2 from December 14, 2020, to April 19, 2022, with follow-up un2022-01-01T00:00:00Z2022 Oct2025-04-04T21:55:07.405Z2025-04-04T21:55:07.405ZS-EPMC95799103625542610.1001/jama.2022.18550