biostudies-literatureChung DWNIMH NIH HHS277-287https://www.ebi.ac.uk/biostudies/studies/S-EPMC9580070biostudies-literatureUnknown179(4)<h4>Objective</h4>Cognitive impairments in schizophrenia are associated with lower gamma oscillation power in the prefrontal cortex (PFC). Gamma power depends in part on excitatory drive to fast-spiking parvalbumin interneurons (PVIs). Excitatory drive to cortical neurons varies in strength, which could affect how these neurons regulate network oscillations. The authors investigated whether variability in excitatory synaptic strength across PVIs could contribute to lower prefrontal gamma power in schizophrenia.<h4>Methods</h4>In postmortem PFC from 20 matched pairs of comparison and schizophrenia subjects, levels of vesicular glutamate transporter 1 (VGlut1) and postsynaptic density 95 (PSD95) proteins were quantified to assess variability in excitatory synaptic strength across PVIs. A comThe American journal of psychiatrySynaptic Variability and Cortical Gamma Oscillation Power in Schizophrenia.PMC9580070R01 MH043784P50 MH103204Chung DWGeramita MALewis DAfalseSynaptic Variability and Cortical Gamma Oscillation Power in Schizophrenia.<h4>Objective</h4>Cognitive impairments in schizophrenia are associated with lower gamma oscillation power in the prefrontal cortex (PFC). Gamma power depends in part on excitatory drive to fast-spiking parvalbumin interneurons (PVIs). Excitatory drive to cortical neurons varies in strength, which could affect how these neurons regulate network oscillations. The authors investigated whether variability in excitatory synaptic strength across PVIs could contribute to lower prefrontal gamma power in schizophrenia.<h4>Methods</h4>In postmortem PFC from 20 matched pairs of comparison and schizophrenia subjects, levels of vesicular glutamate transporter 1 (VGlut1) and postsynaptic density 95 (PSD95) proteins were quantified to assess variability in excitatory synaptic strength across PVIs. A com2022-01-01T00:00:00Z2022 Apr2025-04-04T07:26:53.377Z2025-04-04T07:26:53.377ZS-EPMC95800703536091910.1176/appi.ajp.2021.21080798