{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(40)"],"submitter":["Okafor M"],"pubmed_abstract":["Copper (Cu) in its ionic forms is an essential element for mammals and its homeostasis is tightly controlled. Accordingly, Cu-dyshomeostasis can be lethal as is the case in the well-established genetic Wilson's and Menkes diseases. In Alzheimer's disease (AD), Cu-accumulation occurs in amyloid plaques, where it is bound to the amyloid-beta peptide (Aβ). <i>In vitro</i>, Cu-Aβ is competent to catalyze the production of reactive oxygen species (ROS) in the presence of ascorbate under aerobic conditions, and hence Cu-Aβ is believed to contribute to the oxidative stress in AD. Several molecules that can recover extracellular Cu from Aβ and transport it back into cells with beneficial effects in cell culture and transgenic AD models were identified. However, all the Cu-shuttles currently availa"],"journal":["Chemical science"],"pagination":["11829-11840"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9580518"],"repository":["biostudies-literature"],"pubmed_title":["Development of Cu(ii)-specific peptide shuttles capable of preventing Cu-amyloid beta toxicity and importing bioavailable Cu into cells."],"pmcid":["PMC9580518"],"pubmed_authors":["Raibaut L","El Masoudi I","Boos A","Faller P","Hureau C","Ory S","Chasserot-Golaz S","Vitale N","Ronot P","Okafor M","Gasman S","Gonzalez P"],"additional_accession":[]},"is_claimable":false,"name":"Development of Cu(ii)-specific peptide shuttles capable of preventing Cu-amyloid beta toxicity and importing bioavailable Cu into cells.","description":"Copper (Cu) in its ionic forms is an essential element for mammals and its homeostasis is tightly controlled. Accordingly, Cu-dyshomeostasis can be lethal as is the case in the well-established genetic Wilson's and Menkes diseases. In Alzheimer's disease (AD), Cu-accumulation occurs in amyloid plaques, where it is bound to the amyloid-beta peptide (Aβ). <i>In vitro</i>, Cu-Aβ is competent to catalyze the production of reactive oxygen species (ROS) in the presence of ascorbate under aerobic conditions, and hence Cu-Aβ is believed to contribute to the oxidative stress in AD. Several molecules that can recover extracellular Cu from Aβ and transport it back into cells with beneficial effects in cell culture and transgenic AD models were identified. However, all the Cu-shuttles currently availa","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-04-05T13:28:05.648Z","creation":"2025-04-05T13:28:05.648Z"},"accession":"S-EPMC9580518","cross_references":{"pubmed":["36320914"],"doi":["10.1039/d2sc02593k"]}}