biostudies-literatureUnknown7(41)Mohamed ASThe synthesis with structural identifications including NMR and HRMS spectral data along with single-crystal X-ray diffraction analysis (for <b>20b</b>, <b>23b</b>, <b>25b</b>-<b>27b</b>) of a family of 14 new <i>syn</i>/<i>anti</i> bis-4-spiro-β-lactam-based unsaturated macrocycles (<b>19a</b>,<b>b-27a</b>,<b>b</b>), obtained by multistep synthesis including (i) diimine formation, (ii) Staudinger [2 + 2] ketene-imine cycloaddition, and (iii) ring-closing metathesis (RCM), is reported.ACS omega36795-36803https://www.ebi.ac.uk/biostudies/studies/S-EPMC9583306biostudies-literatureVariable-Sized bis(4-spiro-fused-β-lactam)-Based Unsaturated Macrocycles: Synthesis and Characterization.PMC9583306Al-Awadhi FHMohamed ASAl-Awadi NAfalseVariable-Sized bis(4-spiro-fused-β-lactam)-Based Unsaturated Macrocycles: Synthesis and Characterization.The synthesis with structural identifications including NMR and HRMS spectral data along with single-crystal X-ray diffraction analysis (for <b>20b</b>, <b>23b</b>, <b>25b</b>-<b>27b</b>) of a family of 14 new <i>syn</i>/<i>anti</i> bis-4-spiro-β-lactam-based unsaturated macrocycles (<b>19a</b>,<b>b-27a</b>,<b>b</b>), obtained by multistep synthesis including (i) diimine formation, (ii) Staudinger [2 + 2] ketene-imine cycloaddition, and (iii) ring-closing metathesis (RCM), is reported.2022-01-01T00:00:00Z2022 Oct2025-04-26T00:54:21.177Z2025-02-19T03:02:06.493ZS-EPMC95833063627804710.1021/acsomega.2c05212