{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Tang S"],"pubmed_abstract":["Renal clear cell carcinoma (KIRC) is one malignancy whose development and prognosis have been associated with aberrant DHRS7 expression. However, the catalytic activity and pathophysiology of KIRC are poorly understood, and no sensitive tumor biomarkers have yet been discovered. In our study, we examined the significant influence of DHRS7 on the tumor microenvironment (TME) and tumor progression using an overall predictable and prognostic evaluation approach. We found novel cancer staging, particularly in KIRC, as well as potential therapeutic drugs out of 27 drug sensitivity tests. Using Perl scripts, it was possible to determine the number of somatic mutations present in 33 tumors, as well as the relative scores of 22 immune cells using CIBERSORT, the relationship between immune infiltra"],"journal":["Frontiers in genetics"],"pagination":["1015844"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9584615"],"repository":["biostudies-literature"],"pubmed_title":["DHRS7 is an immune-related prognostic biomarker of KIRC and pan-cancer."],"pmcid":["PMC9584615"],"pubmed_authors":["Liu H","El Akkawi MM","Tan Z","Tang S","Chen G","Wang Y","Liu D","Zhao Z"],"additional_accession":[]},"is_claimable":false,"name":"DHRS7 is an immune-related prognostic biomarker of KIRC and pan-cancer.","description":"Renal clear cell carcinoma (KIRC) is one malignancy whose development and prognosis have been associated with aberrant DHRS7 expression. However, the catalytic activity and pathophysiology of KIRC are poorly understood, and no sensitive tumor biomarkers have yet been discovered. In our study, we examined the significant influence of DHRS7 on the tumor microenvironment (TME) and tumor progression using an overall predictable and prognostic evaluation approach. We found novel cancer staging, particularly in KIRC, as well as potential therapeutic drugs out of 27 drug sensitivity tests. Using Perl scripts, it was possible to determine the number of somatic mutations present in 33 tumors, as well as the relative scores of 22 immune cells using CIBERSORT, the relationship between immune infiltra","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-26T00:53:55.802Z","creation":"2025-02-19T03:02:12.569Z"},"accession":"S-EPMC9584615","cross_references":{"pubmed":["36276963"],"doi":["10.3389/fgene.2022.1015844"]}}