{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["2022"],"submitter":["Tao JH"],"pubmed_abstract":["<h4>Background</h4>Epoxyeicosatrienoic acids (EETs), the metabolite of arachidonic acid by cytochrome P450 (CYP), reportedly serve as a vital endogenous protective factor in several chronic diseases. EETs are metabolized by soluble epoxide hydrolase (sEH). We have observed that prophylactic blocking sEH alleviates bleomycin- (BLM-) induced pulmonary fibrosis (PF) in mice. However, the underlying mechanism and therapeutic effects of EETs on PF remain elusive.<h4>Objective</h4>In this study, we investigated the effect of CYP2J2/EETs on the activation of murine fibroblasts and their mechanisms.<h4>Results</h4>we found that administration of the sEH inhibitor (TPPU) 7 days after the BLM injection also reversed the morphology changes and collagen deposition in the lungs of BLM-treated mice, att"],"journal":["Oxidative medicine and cellular longevity"],"pagination":["7265486"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9584742"],"repository":["biostudies-literature"],"pubmed_title":["Epoxyeicosatrienoic Acids Inhibit the Activation of Murine Fibroblasts by Blocking the TGF-<i>β</i>1-Smad2/3 Signaling in a PPAR<i>γ</i>-Dependent Manner."],"pmcid":["PMC9584742"],"pubmed_authors":["Guan CX","Yang HH","Zu C","Yang JT","Tao JH","Liu T","Liu YB","Zhou Y","Zhang CY"],"additional_accession":[]},"is_claimable":false,"name":"Epoxyeicosatrienoic Acids Inhibit the Activation of Murine Fibroblasts by Blocking the TGF-<i>β</i>1-Smad2/3 Signaling in a PPAR<i>γ</i>-Dependent Manner.","description":"<h4>Background</h4>Epoxyeicosatrienoic acids (EETs), the metabolite of arachidonic acid by cytochrome P450 (CYP), reportedly serve as a vital endogenous protective factor in several chronic diseases. EETs are metabolized by soluble epoxide hydrolase (sEH). We have observed that prophylactic blocking sEH alleviates bleomycin- (BLM-) induced pulmonary fibrosis (PF) in mice. However, the underlying mechanism and therapeutic effects of EETs on PF remain elusive.<h4>Objective</h4>In this study, we investigated the effect of CYP2J2/EETs on the activation of murine fibroblasts and their mechanisms.<h4>Results</h4>we found that administration of the sEH inhibitor (TPPU) 7 days after the BLM injection also reversed the morphology changes and collagen deposition in the lungs of BLM-treated mice, att","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-26T00:52:26.185Z","creation":"2024-12-03T23:44:12.08Z"},"accession":"S-EPMC9584742","cross_references":{"pubmed":["36275905"],"doi":["10.1155/2022/7265486"]}}