{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tam S"],"funding":["National Health and Medical Research Council","University of Sydney"],"pagination":["998-1010"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9584993"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["74(5)"],"pubmed_abstract":["Background
The lack of drug targets is an obstacle to the treatment of patients with triple-negative breast cancer (TNBC). At present, non-specific cytotoxic drugs are first-line agents, but the development of resistance is a major problem with these agents. The epidermal growth factor receptor (EGFR) is a potential target in some TNBCs, because its tyrosine kinase activity drives tumorigenesis. Thus, small molecule inhibitors of the EGFR in combination with cytotoxic agents could be important for the treatment of TNBCs.Methods
The present study evaluated the efficacies of clinically approved EGFR inhibitors in combination with the cytotoxic agent ixabepilone in parental and docetaxel-resistant MDA-MB-231 cells (231C and TXT cells, respectively). Cell viability was assessed"],"journal":["Pharmacological reports : PR"],"pubmed_title":["The ixabepilone and vandetanib combination shows synergistic activity in docetaxel-resistant MDA-MB-231 breast cancer cells."],"pmcid":["PMC9584993"],"funding_grant_id":["1145424"],"pubmed_authors":["Rahman MK","Bourget K","Zhou F","Al-Zubaidi Y","Murray M","Tam S"],"additional_accession":[]},"is_claimable":false,"name":"The ixabepilone and vandetanib combination shows synergistic activity in docetaxel-resistant MDA-MB-231 breast cancer cells.","description":"Background
The lack of drug targets is an obstacle to the treatment of patients with triple-negative breast cancer (TNBC). At present, non-specific cytotoxic drugs are first-line agents, but the development of resistance is a major problem with these agents. The epidermal growth factor receptor (EGFR) is a potential target in some TNBCs, because its tyrosine kinase activity drives tumorigenesis. Thus, small molecule inhibitors of the EGFR in combination with cytotoxic agents could be important for the treatment of TNBCs.Methods
The present study evaluated the efficacies of clinically approved EGFR inhibitors in combination with the cytotoxic agent ixabepilone in parental and docetaxel-resistant MDA-MB-231 cells (231C and TXT cells, respectively). Cell viability was assessed","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2026-05-28T01:04:32.987Z","creation":"2025-04-19T22:48:16.052Z"},"accession":"S-EPMC9584993","cross_references":{"pubmed":["35908023"],"doi":["10.1007/s43440-022-00396-7"]}}