biostudies-literatureHrdy JAgence Nationale de la Recherche (France)Agence Nationale de la RechercheCharles University research program CooperationFEDERRegion Centre Val de Loire17591https://www.ebi.ac.uk/biostudies/studies/S-EPMC9585059biostudies-literatureUnknown12(1)Live biotherapeutic products constitute an emerging therapeutic approach to prevent or treat inflammatory bowel diseases. Lactobacillus acidophilus is a constituent of the human microbiota with probiotic potential, that is illustrated by improvement of intestinal inflammation and antimicrobial activity against several pathogens. In this study, we evaluated the immunomodulatory properties of the L. acidophilus strain BIO5768 at steady state and upon acute inflammation. Supplementation of naïve mice with BIO5768 heightened the transcript level of some IL-17 target genes encoding for protein with microbicidal activity independently of NOD2 signaling. Of these, the BIO5768-induced expression of Angiogenin-4 was blunted in monocolonized mice that are deficient for the receptor of IL-17 (but notScientific reportsOral supplementation with selected Lactobacillus acidophilus triggers IL-17-dependent innate defense response, activation of innate lymphoid cells type 3 and improves colitis.PMC9585059IMMU 2070322016-001103662003-00085470EX005756ANR-12-RPIB-0014Lapadatescu CChamaillard MBoutillier DGrangette CHrdy JPot BBlanc PRyffel BCouturier-Maillard AProchazka JfalseOral supplementation with selected Lactobacillus acidophilus triggers IL-17-dependent innate defense response, activation of innate lymphoid cells type 3 and improves colitis.Live biotherapeutic products constitute an emerging therapeutic approach to prevent or treat inflammatory bowel diseases. Lactobacillus acidophilus is a constituent of the human microbiota with probiotic potential, that is illustrated by improvement of intestinal inflammation and antimicrobial activity against several pathogens. In this study, we evaluated the immunomodulatory properties of the L. acidophilus strain BIO5768 at steady state and upon acute inflammation. Supplementation of naïve mice with BIO5768 heightened the transcript level of some IL-17 target genes encoding for protein with microbicidal activity independently of NOD2 signaling. Of these, the BIO5768-induced expression of Angiogenin-4 was blunted in monocolonized mice that are deficient for the receptor of IL-17 (but not2022-01-01T00:00:00Z2022 Oct2025-04-18T22:12:26.173Z2025-02-18T23:58:48.036ZS-EPMC95850593626639810.1038/s41598-022-21643-0