biostudies-literatureBordat ALa Ligue contre le CancerUniversit?? Paris-SaclaySATT Paris-SaclayCentre National de la Recherche ScientifiqueEuropean Commission18844-18860https://www.ebi.ac.uk/biostudies/studies/S-EPMC9585574biostudies-literatureUnknown144(41)Chemotherapy is almost exclusively administered via the intravenous (IV) route, which has serious limitations (e.g., patient discomfort, long hospital stays, need for trained staff, high cost, catheter failures, infections). Therefore, the development of effective and less costly chemotherapy that is more comfortable for the patient would revolutionize cancer therapy. While subcutaneous (SC) administration has the potential to meet these criteria, it is extremely restrictive as it cannot be applied to most anticancer drugs, such as irritant or vesicant ones, for local toxicity reasons. Herein, we report a facile, general, and scalable approach for the SC administration of anticancer drugs through the design of well-defined hydrophilic polymer prodrugs. This was applied to the anticancer drJournal of the American Chemical SocietyA Polymer Prodrug Strategy to Switch from Intravenous to Subcutaneous Cancer Therapy for Irritant/Vesicant Drugs.PMC9585574771829Ferrere MNicolas JGarcia-Argote SLeveque MDenis SBordat AAbadie JPieters GBoissenot TPotiron LCarvalho OTsapis NCailleau CIbrahim NfalseA Polymer Prodrug Strategy to Switch from Intravenous to Subcutaneous Cancer Therapy for Irritant/Vesicant Drugs.Chemotherapy is almost exclusively administered via the intravenous (IV) route, which has serious limitations (e.g., patient discomfort, long hospital stays, need for trained staff, high cost, catheter failures, infections). Therefore, the development of effective and less costly chemotherapy that is more comfortable for the patient would revolutionize cancer therapy. While subcutaneous (SC) administration has the potential to meet these criteria, it is extremely restrictive as it cannot be applied to most anticancer drugs, such as irritant or vesicant ones, for local toxicity reasons. Herein, we report a facile, general, and scalable approach for the SC administration of anticancer drugs through the design of well-defined hydrophilic polymer prodrugs. This was applied to the anticancer dr2022-01-01T00:00:00Z2022 Oct2025-04-19T21:19:49.814Z2025-02-18T23:59:08.885ZS-EPMC95855743619355110.1021/jacs.2c04944