{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["1(1)"],"submitter":["Jacobs ME"],"pubmed_abstract":["<h4>Objectives</h4>Signals at the contact site of antigen-presenting cells (APCs) and T cells help orchestrate the adaptive immune response. CD155 on APCs can interact with the stimulatory receptor DNAM1 or inhibitory receptor TIGIT on T cells. The CD155/DNAM1/TIGIT axis is under extensive investigation as immunotherapy target in inflammatory diseases including cancer, chronic infection and autoimmune diseases. We investigated a possible role for CD155/DNAM1/TIGIT signaling in psoriatic disease.<h4>Methods</h4>By flow cytometry, we analyzed peripheral blood mononuclear cells of patients with psoriasis (<i>n</i> = 20) or psoriatic arthritis (<i>n</i> = 21), and healthy individuals (<i>n</i> = 7). We measured CD155, TIGIT, and DNAM1 expression on leukocyte subsets and compared activation-ind"],"journal":["Immunotherapy advances"],"pagination":["ltaa004"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9585685"],"repository":["biostudies-literature"],"pubmed_title":["DNAM1 and TIGIT balance the T cell response, with low T cell TIGIT expression corresponding to inflammation in psoriatic disease."],"pmcid":["PMC9585685"],"pubmed_authors":["Pouw JN","Olde Nordkamp MA","Radstake TRDJ","Jacobs ME","Boes M","Leijten EFA"],"additional_accession":[]},"is_claimable":false,"name":"DNAM1 and TIGIT balance the T cell response, with low T cell TIGIT expression corresponding to inflammation in psoriatic disease.","description":"<h4>Objectives</h4>Signals at the contact site of antigen-presenting cells (APCs) and T cells help orchestrate the adaptive immune response. CD155 on APCs can interact with the stimulatory receptor DNAM1 or inhibitory receptor TIGIT on T cells. The CD155/DNAM1/TIGIT axis is under extensive investigation as immunotherapy target in inflammatory diseases including cancer, chronic infection and autoimmune diseases. We investigated a possible role for CD155/DNAM1/TIGIT signaling in psoriatic disease.<h4>Methods</h4>By flow cytometry, we analyzed peripheral blood mononuclear cells of patients with psoriasis (<i>n</i> = 20) or psoriatic arthritis (<i>n</i> = 21), and healthy individuals (<i>n</i> = 7). We measured CD155, TIGIT, and DNAM1 expression on leukocyte subsets and compared activation-ind","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jan","modification":"2025-05-18T11:12:19.367Z","creation":"2025-05-18T11:12:19.367Z"},"accession":"S-EPMC9585685","cross_references":{"pubmed":["36284900"],"doi":["10.1093/immadv/ltaa004"]}}