biostudies-literatureUnknown1(1)Jacobs ME<h4>Objectives</h4>Signals at the contact site of antigen-presenting cells (APCs) and T cells help orchestrate the adaptive immune response. CD155 on APCs can interact with the stimulatory receptor DNAM1 or inhibitory receptor TIGIT on T cells. The CD155/DNAM1/TIGIT axis is under extensive investigation as immunotherapy target in inflammatory diseases including cancer, chronic infection and autoimmune diseases. We investigated a possible role for CD155/DNAM1/TIGIT signaling in psoriatic disease.<h4>Methods</h4>By flow cytometry, we analyzed peripheral blood mononuclear cells of patients with psoriasis (<i>n</i> = 20) or psoriatic arthritis (<i>n</i> = 21), and healthy individuals (<i>n</i> = 7). We measured CD155, TIGIT, and DNAM1 expression on leukocyte subsets and compared activation-indImmunotherapy advancesltaa004https://www.ebi.ac.uk/biostudies/studies/S-EPMC9585685biostudies-literatureDNAM1 and TIGIT balance the T cell response, with low T cell TIGIT expression corresponding to inflammation in psoriatic disease.PMC9585685Pouw JNOlde Nordkamp MARadstake TRDJJacobs MEBoes MLeijten EFAfalseDNAM1 and TIGIT balance the T cell response, with low T cell TIGIT expression corresponding to inflammation in psoriatic disease.<h4>Objectives</h4>Signals at the contact site of antigen-presenting cells (APCs) and T cells help orchestrate the adaptive immune response. CD155 on APCs can interact with the stimulatory receptor DNAM1 or inhibitory receptor TIGIT on T cells. The CD155/DNAM1/TIGIT axis is under extensive investigation as immunotherapy target in inflammatory diseases including cancer, chronic infection and autoimmune diseases. We investigated a possible role for CD155/DNAM1/TIGIT signaling in psoriatic disease.<h4>Methods</h4>By flow cytometry, we analyzed peripheral blood mononuclear cells of patients with psoriasis (<i>n</i> = 20) or psoriatic arthritis (<i>n</i> = 21), and healthy individuals (<i>n</i> = 7). We measured CD155, TIGIT, and DNAM1 expression on leukocyte subsets and compared activation-ind2021-01-01T00:00:00Z2021 Jan2025-05-18T11:12:19.367Z2025-05-18T11:12:19.367ZS-EPMC95856853628490010.1093/immadv/ltaa004