{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Nuotio ML"],"funding":["Sydäntutkimussäätiö","the Finnish Foundation for Cardiovascular Research","Sigrid Jusélius Foundation"],"pagination":["1432-1445"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9586691"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(11)"],"pubmed_abstract":["Essential hypertension remains the leading risk factor of global disease burden, but its treatment goals are often not met. We investigated whether DNA methylation is associated with antihypertensive responses to a diuretic, a beta-blocker, a calcium channel blocker or an angiotensin receptor antagonist. In addition, since we previously showed an SNP at the transcription start site (TSS) of the catecholamine biosynthesis-related <i>ACY3</i> gene to associate with blood pressure (BP) response to beta-blockers, we specifically analysed the association of methylation sites close to the <i>ACY3</i> TSS with BP responses to beta-blockers. We conducted an epigenome-wide association study between leukocyte DNA methylation and BP responses to antihypertensive monotherapies in two hypertensive Finn"],"journal":["Epigenetics"],"pubmed_title":["Pharmacoepigenetics of hypertension: genome-wide methylation analysis of responsiveness to four classes of antihypertensive drugs using a double-blind crossover study design."],"pmcid":["PMC9586691"],"funding_grant_id":["08042019KK","20032019KK"],"pubmed_authors":["Sanez Tahtisalo H","Lahtinen A","Donner K","Fyhrquist F","Kontula KK","Hiltunen TP","Nuotio ML","Perola M"],"additional_accession":[]},"is_claimable":false,"name":"Pharmacoepigenetics of hypertension: genome-wide methylation analysis of responsiveness to four classes of antihypertensive drugs using a double-blind crossover study design.","description":"Essential hypertension remains the leading risk factor of global disease burden, but its treatment goals are often not met. We investigated whether DNA methylation is associated with antihypertensive responses to a diuretic, a beta-blocker, a calcium channel blocker or an angiotensin receptor antagonist. In addition, since we previously showed an SNP at the transcription start site (TSS) of the catecholamine biosynthesis-related <i>ACY3</i> gene to associate with blood pressure (BP) response to beta-blockers, we specifically analysed the association of methylation sites close to the <i>ACY3</i> TSS with BP responses to beta-blockers. We conducted an epigenome-wide association study between leukocyte DNA methylation and BP responses to antihypertensive monotherapies in two hypertensive Finn","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2026-04-08T11:39:52.645Z","creation":"2025-04-19T22:47:03.628Z"},"accession":"S-EPMC9586691","cross_references":{"pubmed":["35213289"],"doi":["10.1080/15592294.2022.2038418"]}}