biostudies-literatureNuotio MLSydäntutkimussäätiöthe Finnish Foundation for Cardiovascular ResearchSigrid Jusélius Foundation1432-1445https://www.ebi.ac.uk/biostudies/studies/S-EPMC9586691biostudies-literatureUnknown17(11)Essential hypertension remains the leading risk factor of global disease burden, but its treatment goals are often not met. We investigated whether DNA methylation is associated with antihypertensive responses to a diuretic, a beta-blocker, a calcium channel blocker or an angiotensin receptor antagonist. In addition, since we previously showed an SNP at the transcription start site (TSS) of the catecholamine biosynthesis-related <i>ACY3</i> gene to associate with blood pressure (BP) response to beta-blockers, we specifically analysed the association of methylation sites close to the <i>ACY3</i> TSS with BP responses to beta-blockers. We conducted an epigenome-wide association study between leukocyte DNA methylation and BP responses to antihypertensive monotherapies in two hypertensive FinnEpigeneticsPharmacoepigenetics of hypertension: genome-wide methylation analysis of responsiveness to four classes of antihypertensive drugs using a double-blind crossover study design.PMC958669108042019KK20032019KKSanez Tahtisalo HLahtinen ADonner KFyhrquist FKontula KKHiltunen TPNuotio MLPerola MfalsePharmacoepigenetics of hypertension: genome-wide methylation analysis of responsiveness to four classes of antihypertensive drugs using a double-blind crossover study design.Essential hypertension remains the leading risk factor of global disease burden, but its treatment goals are often not met. We investigated whether DNA methylation is associated with antihypertensive responses to a diuretic, a beta-blocker, a calcium channel blocker or an angiotensin receptor antagonist. In addition, since we previously showed an SNP at the transcription start site (TSS) of the catecholamine biosynthesis-related <i>ACY3</i> gene to associate with blood pressure (BP) response to beta-blockers, we specifically analysed the association of methylation sites close to the <i>ACY3</i> TSS with BP responses to beta-blockers. We conducted an epigenome-wide association study between leukocyte DNA methylation and BP responses to antihypertensive monotherapies in two hypertensive Finn2022-01-01T00:00:00Z2022 Nov2026-04-08T11:39:52.645Z2025-04-19T22:47:03.628ZS-EPMC95866913521328910.1080/15592294.2022.2038418