{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(1)"],"submitter":["Zhou L"],"pubmed_abstract":["Deoxyribonucleic acid (DNA) is the blueprint of life, and cost-effective methods for its long-term storage could have many potential benefits to society. Here we present the method of in situ cryosilicification of whole blood cells, which allows long-term preservation of DNA. Importantly, our straightforward approach is inexpensive, reliable, and yields cryosilicified samples that fulfill the essential criteria for safe, long-term DNA preservation, namely robustness against external stressors, such as radical oxygen species or ultraviolet radiation, and long-term stability in humid conditions at elevated temperatures. Our approach could enable the room temperature storage of genomic information in book-size format for more than one thousand years (thermally equivalent), costing only 0.5 $/"],"journal":["Nature communications"],"pagination":["6265"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9587218"],"repository":["biostudies-literature"],"pubmed_title":["Long-term whole blood DNA preservation by cost-efficient cryosilicification."],"pmcid":["PMC9587218"],"pubmed_authors":["Zhou L","Yin W","Cao J","Wuttke S","Yu H","Ettlinger R","Guo J","Gao Y","Jeffrey Brinker C","Andreo J","Zhu W","Shi J","Xiao B","Lei Q"],"additional_accession":[]},"is_claimable":false,"name":"Long-term whole blood DNA preservation by cost-efficient cryosilicification.","description":"Deoxyribonucleic acid (DNA) is the blueprint of life, and cost-effective methods for its long-term storage could have many potential benefits to society. Here we present the method of in situ cryosilicification of whole blood cells, which allows long-term preservation of DNA. Importantly, our straightforward approach is inexpensive, reliable, and yields cryosilicified samples that fulfill the essential criteria for safe, long-term DNA preservation, namely robustness against external stressors, such as radical oxygen species or ultraviolet radiation, and long-term stability in humid conditions at elevated temperatures. Our approach could enable the room temperature storage of genomic information in book-size format for more than one thousand years (thermally equivalent), costing only 0.5 $/","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-04-26T00:54:23.07Z","creation":"2025-04-06T09:53:43.583Z"},"accession":"S-EPMC9587218","cross_references":{"pubmed":["36270991"],"doi":["10.1038/s41467-022-33759-y"]}}