{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liu J"],"funding":["National Natural Science Foundation of China"],"pagination":["41"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9587650"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["159(1)"],"pubmed_abstract":["<h4>Background</h4>ATM (ataxia-telangiectasia mutated) protein kinase is highly conserved in metazoan, and plays a critical role at DNA damage response, oxidative stress, metabolic stress, immunity, RNA biogenesis etc. Systemic profiling of ATM regulated genes, including protein-coding genes, miRNAs, and long non-coding RNAs, will greatly improve our understanding of ATM functions and its regulation.  RESULTS: 1) differentially expressed protein-coding genes, miRNAs, and long non-coding RNAs in atm mutated flies were identified at physiological condition and after X-ray irradiation. 2) functions of differentially expressed genes in atm mutated flies, regardless of protein-coding genes or non-coding RNAs, are closely related with metabolic process, immune response, DNA damage response or ox"],"journal":["Hereditas"],"pubmed_title":["Profiling ATM regulated genes in Drosophila at physiological condition and after ionizing radiation."],"pmcid":["PMC9587650"],"funding_grant_id":["31771437","31970605","31900484"],"pubmed_authors":["Bi X","Liu J","Xie G","Jin T","Ran L","Zhu R","Zhao Z"],"additional_accession":[]},"is_claimable":false,"name":"Profiling ATM regulated genes in Drosophila at physiological condition and after ionizing radiation.","description":"<h4>Background</h4>ATM (ataxia-telangiectasia mutated) protein kinase is highly conserved in metazoan, and plays a critical role at DNA damage response, oxidative stress, metabolic stress, immunity, RNA biogenesis etc. Systemic profiling of ATM regulated genes, including protein-coding genes, miRNAs, and long non-coding RNAs, will greatly improve our understanding of ATM functions and its regulation.  RESULTS: 1) differentially expressed protein-coding genes, miRNAs, and long non-coding RNAs in atm mutated flies were identified at physiological condition and after X-ray irradiation. 2) functions of differentially expressed genes in atm mutated flies, regardless of protein-coding genes or non-coding RNAs, are closely related with metabolic process, immune response, DNA damage response or ox","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-04-18T22:27:43.524Z","creation":"2025-02-18T23:59:14.367Z"},"accession":"S-EPMC9587650","cross_references":{"pubmed":["36271387"],"doi":["10.1186/s41065-022-00254-9"]}}