biostudies-literatureLiu JNational Natural Science Foundation of China41https://www.ebi.ac.uk/biostudies/studies/S-EPMC9587650biostudies-literatureUnknown159(1)<h4>Background</h4>ATM (ataxia-telangiectasia mutated) protein kinase is highly conserved in metazoan, and plays a critical role at DNA damage response, oxidative stress, metabolic stress, immunity, RNA biogenesis etc. Systemic profiling of ATM regulated genes, including protein-coding genes, miRNAs, and long non-coding RNAs, will greatly improve our understanding of ATM functions and its regulation.  RESULTS: 1) differentially expressed protein-coding genes, miRNAs, and long non-coding RNAs in atm mutated flies were identified at physiological condition and after X-ray irradiation. 2) functions of differentially expressed genes in atm mutated flies, regardless of protein-coding genes or non-coding RNAs, are closely related with metabolic process, immune response, DNA damage response or oxHereditasProfiling ATM regulated genes in Drosophila at physiological condition and after ionizing radiation.PMC9587650317714373197060531900484Bi XLiu JXie GJin TRan LZhu RZhao ZfalseProfiling ATM regulated genes in Drosophila at physiological condition and after ionizing radiation.<h4>Background</h4>ATM (ataxia-telangiectasia mutated) protein kinase is highly conserved in metazoan, and plays a critical role at DNA damage response, oxidative stress, metabolic stress, immunity, RNA biogenesis etc. Systemic profiling of ATM regulated genes, including protein-coding genes, miRNAs, and long non-coding RNAs, will greatly improve our understanding of ATM functions and its regulation.  RESULTS: 1) differentially expressed protein-coding genes, miRNAs, and long non-coding RNAs in atm mutated flies were identified at physiological condition and after X-ray irradiation. 2) functions of differentially expressed genes in atm mutated flies, regardless of protein-coding genes or non-coding RNAs, are closely related with metabolic process, immune response, DNA damage response or ox2022-01-01T00:00:00Z2022 Oct2025-04-18T22:27:43.524Z2025-02-18T23:59:14.367ZS-EPMC95876503627138710.1186/s41065-022-00254-9