biostudies-literatureChock VYNHLBI NIH HHS1034-1041https://www.ebi.ac.uk/biostudies/studies/S-EPMC9588487biostudies-literatureUnknown92(4)<h4>Background</h4>Extremely low birth weight (ELBW) infants are at risk for end-organ hypoxia and ischemia. Regional tissue oxygenation of the brain and gut as monitored with near-infrared spectroscopy (NIRS) may change with postnatal age, but normal ranges are not well defined.<h4>Methods</h4>A prospective study of ELBW preterm infants utilized NIRS monitoring to assess changes in cerebral and mesenteric saturation (Csat and Msat) over the first week after birth. This secondary study of a multicenter trial comparing hemoglobin transfusion thresholds assessed cerebral and mesenteric fractional tissue oxygen extraction (cFTOE and mFTOE) and relationships with perinatal variables.<h4>Results</h4>In 124 infants, both Csat and Msat declined over the first week, with a corresponding increase iPediatric researchEarly brain and abdominal oxygenation in extremely low birth weight infants.PMC9588487R01 HL122167Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research NetworkSokol GMHiggins RDCarlo WAKirpalani HD'Angio CTSeabrook RBChawla SYoder BAWidness JABell EFCotten CMVan Meurs KPSmith EWalsh MCMancini TBall MBKennedy KAChalak LFOhls RKChock VYLaptook ARTan SPoindexter BBDas APatel RMHintz SRfalseEarly brain and abdominal oxygenation in extremely low birth weight infants.<h4>Background</h4>Extremely low birth weight (ELBW) infants are at risk for end-organ hypoxia and ischemia. Regional tissue oxygenation of the brain and gut as monitored with near-infrared spectroscopy (NIRS) may change with postnatal age, but normal ranges are not well defined.<h4>Methods</h4>A prospective study of ELBW preterm infants utilized NIRS monitoring to assess changes in cerebral and mesenteric saturation (Csat and Msat) over the first week after birth. This secondary study of a multicenter trial comparing hemoglobin transfusion thresholds assessed cerebral and mesenteric fractional tissue oxygen extraction (cFTOE and mFTOE) and relationships with perinatal variables.<h4>Results</h4>In 124 infants, both Csat and Msat declined over the first week, with a corresponding increase i2022-01-01T00:00:00Z2022 Oct2025-04-05T11:57:11.418Z2025-04-05T11:57:11.418ZS-EPMC95884873551371610.1038/s41390-022-02082-z