biostudies-literatureTaylor MLNICHD NIH HHSNIAID NIH HHSNIAMS NIH HHS1042-1051https://www.ebi.ac.uk/biostudies/studies/S-EPMC9588491biostudies-literatureUnknown49(9)<h4>Objective</h4>To compare clinical outcomes in children with hemophagocytic lymphohistiocytosis (HLH) and macrophage activation syndrome (MAS) who were managed before and after implementation of an evidence-based guideline (EBG).<h4>Methods</h4>A management algorithm for MAS-HLH was developed at our institution based on literature review, expert opinion, and consensus building across multiple pediatric subspecialties. An electronic medical record search retrospectively identified hospitalized patients with MAS-HLH in the pre-EBG (October 15, 2015, to December 4, 2017) and post-EBG (January 1, 2018, to January 21, 2020) time periods. Predetermined outcome metrics were evaluated in the 2 cohorts.<h4>Results</h4>After the EBG launch, 57 children were identified by house staff as potential The Journal of rheumatologyAn Evidence-Based Guideline Improves Outcomes for Patients With Hemophagocytic Lymphohistiocytosis and Macrophage Activation Syndrome.PMC9588491K08 AR073339K12 HD052896P30 AR070253T32 AI007512Meidan ESon MBFBenson LLee PYHazen MMHalyabar OChang MHChandler MTCohen EMHausmann JSGorman MCase SLo MSPlatt CDegar BHenderson LATaylor MLLo JPriebe GPNigrovic PAJanssen ERoberts JESundel RPYeun JCHoyt KJDay-Lewis MAlfieri MShobiye DMHan JDedeoglu FChang JCfalseAn Evidence-Based Guideline Improves Outcomes for Patients With Hemophagocytic Lymphohistiocytosis and Macrophage Activation Syndrome.<h4>Objective</h4>To compare clinical outcomes in children with hemophagocytic lymphohistiocytosis (HLH) and macrophage activation syndrome (MAS) who were managed before and after implementation of an evidence-based guideline (EBG).<h4>Methods</h4>A management algorithm for MAS-HLH was developed at our institution based on literature review, expert opinion, and consensus building across multiple pediatric subspecialties. An electronic medical record search retrospectively identified hospitalized patients with MAS-HLH in the pre-EBG (October 15, 2015, to December 4, 2017) and post-EBG (January 1, 2018, to January 21, 2020) time periods. Predetermined outcome metrics were evaluated in the 2 cohorts.<h4>Results</h4>After the EBG launch, 57 children were identified by house staff as potential 2022-01-01T00:00:00Z2022 Sep2025-04-04T20:04:36.169Z2025-04-04T20:04:36.169ZS-EPMC95884913584015610.3899/jrheum.211219