{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12"],"submitter":["Meng F"],"pubmed_abstract":["Drug-eluting bead transarterial chemoembolization (DEB-TACE) has been widely used in the treatment of liver cancer; however, the utilization rate of chemotherapeutic drugs after embolization is low. Chemotherapy resistance mediated by high nuclear factor E2-related factor 2 (NRF2) expression limits DEB-TACE efficacy. Camptothecin (CPT), an NRF2 inhibitor, exerts chemosensitizing effects. We designed a controlled experiment to determine the efficacy and feasibility of DEB-TACE combined with CPT for the treatment of rabbit VX2 hepatoma. DEB-TACE activated NRF2 expression in the tumor region. NRF2 activation could be inhibited by the combined use of CPT. After DEB-TACE alone, the tumor necrosis was incomplete, there were still highly active tumor residues, and the apparent diffusion coefficie"],"journal":["Frontiers in oncology"],"pagination":["906971"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9590107"],"repository":["biostudies-literature"],"pubmed_title":["Experimental study of camptothecin combined with drug-eluting bead transarterial chemoembolization in the rabbit VX2 liver tumor model."],"pmcid":["PMC9590107"],"pubmed_authors":["Meng F","Sun L","Li G","Li X","Li Y","Liu Q","Chen F","Wang H"],"additional_accession":[]},"is_claimable":false,"name":"Experimental study of camptothecin combined with drug-eluting bead transarterial chemoembolization in the rabbit VX2 liver tumor model.","description":"Drug-eluting bead transarterial chemoembolization (DEB-TACE) has been widely used in the treatment of liver cancer; however, the utilization rate of chemotherapeutic drugs after embolization is low. Chemotherapy resistance mediated by high nuclear factor E2-related factor 2 (NRF2) expression limits DEB-TACE efficacy. Camptothecin (CPT), an NRF2 inhibitor, exerts chemosensitizing effects. We designed a controlled experiment to determine the efficacy and feasibility of DEB-TACE combined with CPT for the treatment of rabbit VX2 hepatoma. DEB-TACE activated NRF2 expression in the tumor region. NRF2 activation could be inhibited by the combined use of CPT. After DEB-TACE alone, the tumor necrosis was incomplete, there were still highly active tumor residues, and the apparent diffusion coefficie","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-04T23:19:48.068Z","creation":"2025-04-04T23:19:48.068Z"},"accession":"S-EPMC9590107","cross_references":{"pubmed":["36300094"],"doi":["10.3389/fonc.2022.906971"]}}