{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Cai Y"],"funding":["NCI/NIH","American Cancer Society Research Scholar Grant","NIH","NIH HHS"],"pagination":["61"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9590160"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(1)"],"pubmed_abstract":["<h4>Background</h4>Bile acids are known to be genotoxic and contribute to colorectal cancer (CRC). However, the link between CRC tumor bile acids to tumor location, patient sex, microbiome, immune-regulatory cells, and prognosis is not clear.<h4>Methods</h4>We conducted bile acid analysis using targeted liquid chromatography-mass spectrometry (LC-MS) on tumor tissues from CRC patients (n = 228) with survival analysis. We performed quantitative immunofluorescence (QIF) on tumors to examine immune cells.<h4>Results</h4>Twelve of the bile acids were significantly higher in right-sided colon tumors compared to left-sided colon tumors. Furthermore, in male patients, right-sided colon tumors had elevated secondary bile acids (deoxycholic acid, lithocholic acid, ursodeoxycholic acid) compared to "],"journal":["Biology of sex differences"],"pubmed_title":["Bile acid distributions, sex-specificity, and prognosis in colorectal cancer."],"pmcid":["PMC9590160"],"funding_grant_id":["1R21CA223686-01","134273-RSG-20-065-01-TBE","K12CA215110","R01CA256530"],"pubmed_authors":["Rattray Z","Johnson CH","Huang H","Gaule P","Paty PB","Muca E","Khan SA","Lu L","Rattray NJW","Zhang Y","Lu J","Cai Y","Theriot CM","Ahuja N","Shen X","Yan H"],"additional_accession":[]},"is_claimable":false,"name":"Bile acid distributions, sex-specificity, and prognosis in colorectal cancer.","description":"<h4>Background</h4>Bile acids are known to be genotoxic and contribute to colorectal cancer (CRC). However, the link between CRC tumor bile acids to tumor location, patient sex, microbiome, immune-regulatory cells, and prognosis is not clear.<h4>Methods</h4>We conducted bile acid analysis using targeted liquid chromatography-mass spectrometry (LC-MS) on tumor tissues from CRC patients (n = 228) with survival analysis. We performed quantitative immunofluorescence (QIF) on tumors to examine immune cells.<h4>Results</h4>Twelve of the bile acids were significantly higher in right-sided colon tumors compared to left-sided colon tumors. Furthermore, in male patients, right-sided colon tumors had elevated secondary bile acids (deoxycholic acid, lithocholic acid, ursodeoxycholic acid) compared to ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-04-04T23:19:38.315Z","creation":"2025-04-04T23:19:38.315Z"},"accession":"S-EPMC9590160","cross_references":{"pubmed":["36274154"],"doi":["10.1186/s13293-022-00473-9"]}}