{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(1)"],"submitter":["Vammen L"],"funding":["Riisfort Fonden","Familien Hede Nielsens Fond","Sundhedsvidenskabelige Fakultet, Aarhus Universitet","Sundhed, Region Midtjylland","Augustinus Fonden","Sundhed og Sygdom, Det Frie Forskningsråd"],"pubmed_abstract":["Background
Neurological injury is the primary cause of death after out-of-hospital cardiac arrest. There is a lack of studies investigating cerebral injury beyond the immediate post-resuscitation phase in a controlled cardiac arrest experimental setting.Methods
The aim of this study was to investigate temporal changes in measures of cerebral injury and metabolism in a cardiac arrest pig model with clinically relevant post-cardiac arrest intensive care. A cardiac arrest group (n = 11) underwent 7 min of no-flow and was compared with a sham group (n = 6). Pigs underwent intensive care with 24 h of hypothermia at 33 °C. Blood markers of cerebral injury, cerebral microdialysis, and intracranial pressure (ICP) were measured. After 48 h, pigs underwent a cerebral MRI scan. Data a"],"journal":["Intensive care medicine experimental"],"pagination":["45"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9596181"],"repository":["biostudies-literature"],"pubmed_title":["Cerebral monitoring in a pig model of cardiac arrest with 48 h of intensive care."],"pmcid":["PMC9596181"],"pubmed_authors":["Petersen SR","Vammen L","Lofgren B","Granfeldt A","Azizi A","Korshoj AR","Andersen LW","Magnussen A","Pedersen M","Johannsen CM","Ringgaard S","Povlsen A"],"additional_accession":[]},"is_claimable":false,"name":"Cerebral monitoring in a pig model of cardiac arrest with 48 h of intensive care.","description":"Background
Neurological injury is the primary cause of death after out-of-hospital cardiac arrest. There is a lack of studies investigating cerebral injury beyond the immediate post-resuscitation phase in a controlled cardiac arrest experimental setting.Methods
The aim of this study was to investigate temporal changes in measures of cerebral injury and metabolism in a cardiac arrest pig model with clinically relevant post-cardiac arrest intensive care. A cardiac arrest group (n = 11) underwent 7 min of no-flow and was compared with a sham group (n = 6). Pigs underwent intensive care with 24 h of hypothermia at 33 °C. Blood markers of cerebral injury, cerebral microdialysis, and intracranial pressure (ICP) were measured. After 48 h, pigs underwent a cerebral MRI scan. Data a","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-04-18T11:42:08.148Z","creation":"2024-10-15T01:21:03.2Z"},"accession":"S-EPMC9596181","cross_references":{"pubmed":["36284020"],"doi":["10.1186/s40635-022-00475-2"]}}