biostudies-literatureUnknown10(1)Vammen LRiisfort FondenFamilien Hede Nielsens FondSundhedsvidenskabelige Fakultet, Aarhus UniversitetSundhed, Region MidtjyllandAugustinus FondenSundhed og Sygdom, Det Frie Forskningsråd<h4>Background</h4>Neurological injury is the primary cause of death after out-of-hospital cardiac arrest. There is a lack of studies investigating cerebral injury beyond the immediate post-resuscitation phase in a controlled cardiac arrest experimental setting.<h4>Methods</h4>The aim of this study was to investigate temporal changes in measures of cerebral injury and metabolism in a cardiac arrest pig model with clinically relevant post-cardiac arrest intensive care. A cardiac arrest group (n = 11) underwent 7 min of no-flow and was compared with a sham group (n = 6). Pigs underwent intensive care with 24 h of hypothermia at 33 °C. Blood markers of cerebral injury, cerebral microdialysis, and intracranial pressure (ICP) were measured. After 48 h, pigs underwent a cerebral MRI scan. Data aIntensive care medicine experimental45https://www.ebi.ac.uk/biostudies/studies/S-EPMC9596181biostudies-literatureCerebral monitoring in a pig model of cardiac arrest with 48 h of intensive care.PMC9596181Petersen SRVammen LLofgren BGranfeldt AAzizi AKorshoj ARAndersen LWMagnussen APedersen MJohannsen CMRinggaard SPovlsen AfalseCerebral monitoring in a pig model of cardiac arrest with 48 h of intensive care.<h4>Background</h4>Neurological injury is the primary cause of death after out-of-hospital cardiac arrest. There is a lack of studies investigating cerebral injury beyond the immediate post-resuscitation phase in a controlled cardiac arrest experimental setting.<h4>Methods</h4>The aim of this study was to investigate temporal changes in measures of cerebral injury and metabolism in a cardiac arrest pig model with clinically relevant post-cardiac arrest intensive care. A cardiac arrest group (n = 11) underwent 7 min of no-flow and was compared with a sham group (n = 6). Pigs underwent intensive care with 24 h of hypothermia at 33 °C. Blood markers of cerebral injury, cerebral microdialysis, and intracranial pressure (ICP) were measured. After 48 h, pigs underwent a cerebral MRI scan. Data a2022-01-01T00:00:00Z2022 Oct2025-04-18T11:42:08.148Z2024-10-15T01:21:03.2ZS-EPMC95961813628402010.1186/s40635-022-00475-2