{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["2022"],"submitter":["Han L"],"pubmed_abstract":["Lung cancer is the most diagnosed and deadly cancer in China. MicroRNAs are small noncoding RNA gene products that exhibit multifunctional regulation in cancer cell progressions. MiR-101 loss was illustrated in about 29% of lung cancer patients, and sophisticated mechanisms of miR-101 regulation in NSCLC are eager to be disclosed. Here, using specimens from NSCLC patients and Dural-luciferase reporter assay, we got a clue that miR-101 correlated with IDH2. MiR-101 overexpression and IDH2 deficiency both suppressed NSCLC tumor growth in mice. Moreover, in NSCLC, miR-101 suppressed IDH2 expression levels, further increased <i>α</i>-KG concentration, and finally inhibited the Warburg effect under hypoxic conditions through downregulating HIF1<i>α</i> expression by promoting HIF1<i>α</i> hydroxylation and degradation. In conclusion, miR-101 attenuated the Warburg effect and NSCLC proliferation through IDH2/HIF1<i>α</i> pathway."],"journal":["Oxidative medicine and cellular longevity"],"pagination":["4938811"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9596240"],"repository":["biostudies-literature"],"pubmed_title":["MicroRNA 101 Attenuated NSCLC Proliferation through IDH2/HIF<i>α</i> Axis Suppression in the Warburg Effect."],"pmcid":["PMC9596240"],"pubmed_authors":["Huang C","Han L","Zhao B","Chen Z","Zhang Y","Chen W","Lei G","Yue J"],"additional_accession":[]},"is_claimable":false,"name":"MicroRNA 101 Attenuated NSCLC Proliferation through IDH2/HIF<i>α</i> Axis Suppression in the Warburg Effect.","description":"Lung cancer is the most diagnosed and deadly cancer in China. MicroRNAs are small noncoding RNA gene products that exhibit multifunctional regulation in cancer cell progressions. MiR-101 loss was illustrated in about 29% of lung cancer patients, and sophisticated mechanisms of miR-101 regulation in NSCLC are eager to be disclosed. Here, using specimens from NSCLC patients and Dural-luciferase reporter assay, we got a clue that miR-101 correlated with IDH2. MiR-101 overexpression and IDH2 deficiency both suppressed NSCLC tumor growth in mice. Moreover, in NSCLC, miR-101 suppressed IDH2 expression levels, further increased <i>α</i>-KG concentration, and finally inhibited the Warburg effect under hypoxic conditions through downregulating HIF1<i>α</i> expression by promoting HIF1<i>α</i> hydroxylation and degradation. In conclusion, miR-101 attenuated the Warburg effect and NSCLC proliferation through IDH2/HIF1<i>α</i> pathway.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-04T23:19:26.94Z","creation":"2025-04-04T23:19:26.94Z"},"accession":"S-EPMC9596240","cross_references":{"pubmed":["36304962"],"doi":["10.1155/2022/4938811"]}}