{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ellison CK"],"funding":["NIAID NIH HHS","Damon Runyon Cancer Research Foundation","NIGMS NIH HHS","Division of Intramural Research, National Institute of Allergy and Infectious Diseases"],"pagination":["6334"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9596432"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(1)"],"pubmed_abstract":["In mammals, subcellular protein localization of factors like planar cell polarity proteins is a key driver of the multicellular organization of tissues. Bacteria also form organized multicellular communities, but these patterns are largely thought to emerge from regulation of whole-cell processes like growth, motility, cell shape, and differentiation. Here we show that a unique intracellular patterning of appendages known as type IV pili (T4P) can drive multicellular development of complex bacterial communities. Specifically, dynamic T4P appendages localize in a line along the long axis of the cell in the bacterium Acinetobacter baylyi. This long-axis localization is regulated by a functionally divergent chemosensory Pil-Chp system, and an atypical T4P protein homologue (FimV) bridges Pil-"],"journal":["Nature communications"],"pubmed_title":["Subcellular localization of type IV pili regulates bacterial multicellular development."],"pmcid":["PMC9596432"],"funding_grant_id":["1DP1AI124669-01","DP1 AI124669","R35 GM128674","R01 GM082938","DRG-2385-20"],"pubmed_authors":["Dalia AB","Gitai Z","Fei C","Wingreen NS","Ellison CK","Shaevitz JW","Dalia TN"],"additional_accession":[]},"is_claimable":false,"name":"Subcellular localization of type IV pili regulates bacterial multicellular development.","description":"In mammals, subcellular protein localization of factors like planar cell polarity proteins is a key driver of the multicellular organization of tissues. Bacteria also form organized multicellular communities, but these patterns are largely thought to emerge from regulation of whole-cell processes like growth, motility, cell shape, and differentiation. Here we show that a unique intracellular patterning of appendages known as type IV pili (T4P) can drive multicellular development of complex bacterial communities. Specifically, dynamic T4P appendages localize in a line along the long axis of the cell in the bacterium Acinetobacter baylyi. This long-axis localization is regulated by a functionally divergent chemosensory Pil-Chp system, and an atypical T4P protein homologue (FimV) bridges Pil-","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2026-06-03T10:34:47.836Z","creation":"2025-04-19T12:05:15.293Z"},"accession":"S-EPMC9596432","cross_references":{"pubmed":["36284096"],"doi":["10.1038/s41467-022-33564-7"]}}