{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Carll AP"],"funding":["U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS)","NHLBI NIH HHS","U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI)","NIGMS NIH HHS"],"pagination":["6088"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9596490"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(1)"],"pubmed_abstract":["E-cigarette use has surged, but the long-term health effects remain unknown. E-cigarette aerosols containing nicotine and acrolein, a combustion and e-cigarette byproduct, may impair cardiac electrophysiology through autonomic imbalance. Here we show in mouse electrocardiograms that acute inhalation of e-cigarette aerosols disturbs cardiac conduction, in part through parasympathetic modulation. We demonstrate that, similar to acrolein or combustible cigarette smoke, aerosols from e-cigarette solvents (vegetable glycerin and propylene glycol) induce bradycardia, bradyarrhythmias, and elevations in heart rate variability during inhalation exposure, with inverse post-exposure effects. These effects are slighter with tobacco- or menthol-flavored aerosols containing nicotine, and in female mice"],"journal":["Nature communications"],"pubmed_title":["E-cigarettes and their lone constituents induce cardiac arrhythmia and conduction defects in mice."],"pmcid":["PMC9596490"],"funding_grant_id":["P30 GM127607","P30GM127607","R01 HL163818","R01HL147343","R01HL163818","R01 HL147343","R01HL122676","P50 HL120163","U54HL120163","R01 HL122676","U54 HL120163"],"pubmed_authors":["Miles MD","Theis WS","Bhatnagar A","Salatini R","Shirk GA","Riggs DW","Nystoriak MA","Conklin DJ","Arab C","Carll AP","Fulghum KL","Talebi N"],"additional_accession":[]},"is_claimable":false,"name":"E-cigarettes and their lone constituents induce cardiac arrhythmia and conduction defects in mice.","description":"E-cigarette use has surged, but the long-term health effects remain unknown. E-cigarette aerosols containing nicotine and acrolein, a combustion and e-cigarette byproduct, may impair cardiac electrophysiology through autonomic imbalance. Here we show in mouse electrocardiograms that acute inhalation of e-cigarette aerosols disturbs cardiac conduction, in part through parasympathetic modulation. We demonstrate that, similar to acrolein or combustible cigarette smoke, aerosols from e-cigarette solvents (vegetable glycerin and propylene glycol) induce bradycardia, bradyarrhythmias, and elevations in heart rate variability during inhalation exposure, with inverse post-exposure effects. These effects are slighter with tobacco- or menthol-flavored aerosols containing nicotine, and in female mice","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-04-18T21:22:31.065Z","creation":"2025-04-07T09:17:32.018Z"},"accession":"S-EPMC9596490","cross_references":{"pubmed":["36284091"],"doi":["10.1038/s41467-022-33203-1"]}}