biostudies-literatureWan FNational Health and Medical Research CouncilUniversity of Tasmania3987-4000https://www.ebi.ac.uk/biostudies/studies/S-EPMC9596520biostudies-literatureUnknown61(8)<h4>Background and aim</h4>Dietary fat intake has long been associated with fatty liver. Our study aimed to determine the effect of dietary fats on longitudinal fatty liver index (FLI) trajectories from adolescence to young adulthood.<h4>Methods</h4>Nine hundred eighty-five participants in the Raine Study, Perth, Western Australia, Australia, had cross-sectional assessments at ages 14, 17, 20 and 22 years, during which anthropometric measurements and blood tests were obtained. FLI trajectories were derived from the longitudinal FLI results. Dietary fat intake was measured with a semi-quantitative food frequency questionnaire at 14 years and log multinominal regression analyses were used to estimate relative risks.<h4>Results</h4>Three FLI trajectories were identified and labelled as stableEuropean journal of nutritionProspective dietary polyunsaturated fatty acid intake is associated with trajectories of fatty liver disease: an 8 year follow-up study from adolescence to young adulthood.PMC959652010274491022134403981211912102110510448401021855003209353514Olynyk JKMori TAAyonrinde OPan FAdams LABeilin LJWan FO'Sullivan TAOddy WHfalseProspective dietary polyunsaturated fatty acid intake is associated with trajectories of fatty liver disease: an 8 year follow-up study from adolescence to young adulthood.<h4>Background and aim</h4>Dietary fat intake has long been associated with fatty liver. Our study aimed to determine the effect of dietary fats on longitudinal fatty liver index (FLI) trajectories from adolescence to young adulthood.<h4>Methods</h4>Nine hundred eighty-five participants in the Raine Study, Perth, Western Australia, Australia, had cross-sectional assessments at ages 14, 17, 20 and 22 years, during which anthropometric measurements and blood tests were obtained. FLI trajectories were derived from the longitudinal FLI results. Dietary fat intake was measured with a semi-quantitative food frequency questionnaire at 14 years and log multinominal regression analyses were used to estimate relative risks.<h4>Results</h4>Three FLI trajectories were identified and labelled as stable2022-01-01T00:00:00Z2022 Dec2026-06-03T10:30:33.063Z2025-04-05T21:24:57.833ZS-EPMC95965203578042410.1007/s00394-022-02934-8