{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12"],"submitter":["Lazcano R"],"pubmed_abstract":["<h4>Introduction</h4>Undifferentiated pleomorphic sarcoma (UPS) can be associated with a relatively dense immune infiltration. Immune checkpoint inhibitors (anti-PD1, anti-PDL1, and anti-CTLA4) are effective in 20% of UPS patients. We characterize the immune microenvironment of UPS and its association with oncologic outcomes.<h4>Material and methods</h4>Surgically resected UPS samples were stained by immunohistochemistry (IHC) for the following: tumor-associated immune cells (CD3, CD8, CD163, CD20), immune checkpoints (stimulatory: OX40, ICOS; inhibitory: PD-L1, LAG3, IDO1, PD1), and the adenosine pathway (CD73, CD39). Sections were reviewed for the presence of lymphoid aggregates (LA). Clinical data were retrospectively obtained for all samples. The Wilcoxon rank-sum and Kruskal-Wallis te"],"journal":["Frontiers in oncology"],"pagination":["1008484"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9597628"],"repository":["biostudies-literature"],"pubmed_title":["The immune landscape of undifferentiated pleomorphic sarcoma."],"pmcid":["PMC9597628"],"pubmed_authors":["Zarzour AM","Lazcano R","Gite S","Ravi V","Lazar AJ","Lu W","Cope B","Traweek RS","Lin HY","Parra ER","Carapeto F","Mehta J","Scally CP","Keung EZ","Barreto CM","Salazar R","Thirasastr P","Livingston JA","Patel S","Conley AP","Benjamin R","Zhou J","Witt RG","Wargo J","Leung CH","Wistuba II","Ingram DR","Roland CL","Ratan R","Ludwig J","Wang WL","Solis L","Araujo D","Vu KT","Somaiah N","Nassif EF","Wani KM"],"additional_accession":[]},"is_claimable":false,"name":"The immune landscape of undifferentiated pleomorphic sarcoma.","description":"<h4>Introduction</h4>Undifferentiated pleomorphic sarcoma (UPS) can be associated with a relatively dense immune infiltration. Immune checkpoint inhibitors (anti-PD1, anti-PDL1, and anti-CTLA4) are effective in 20% of UPS patients. We characterize the immune microenvironment of UPS and its association with oncologic outcomes.<h4>Material and methods</h4>Surgically resected UPS samples were stained by immunohistochemistry (IHC) for the following: tumor-associated immune cells (CD3, CD8, CD163, CD20), immune checkpoints (stimulatory: OX40, ICOS; inhibitory: PD-L1, LAG3, IDO1, PD1), and the adenosine pathway (CD73, CD39). Sections were reviewed for the presence of lymphoid aggregates (LA). Clinical data were retrospectively obtained for all samples. The Wilcoxon rank-sum and Kruskal-Wallis te","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-22T02:06:02.379Z","creation":"2025-04-05T20:12:35.125Z"},"accession":"S-EPMC9597628","cross_references":{"pubmed":["36313661"],"doi":["10.3389/fonc.2022.1008484"]}}