{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang P"],"funding":["National Natural Science Foundation of China"],"pagination":["1379"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9598136"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(10)"],"pubmed_abstract":["<i>Acinetobacter baumannii</i> is one of the main pathogens causing nosocomial and community-acquired infections. Tigecycline is an important antibiotic for the treatment of multidrug-resistant <i>A. baumannii</i> infections, but strains resistant to tigecycline have also emerged. There are still many unclear questions concerning the mechanism of tigecycline resistance in <i>A. baumannii</i>. In this study, tigecycline-susceptible and tigecycline-intermediate strains were gradually cultured with sub-minimum inhibitory concentrations of tigecycline to select for tigecycline-resistant mutants, and a tigecycline-resistant strain was cultured under 42 °C to select for tigecycline-susceptible mutants. We found that the acquisition of tigecycline resistance affected the susceptibility of the str"],"journal":["Antibiotics (Basel, Switzerland)"],"pubmed_title":["Fitness Costs of Tigecycline Resistance in <i>Acinetobacter baumannii</i> and the Resistance Mechanism Revealed by a Transposon Mutation Library."],"pmcid":["PMC9598136"],"funding_grant_id":["NSFC81572041"],"pubmed_authors":["Wang P","Zou Q","Wang H","Liu C","Feng C","Lu Q"],"additional_accession":[]},"is_claimable":false,"name":"Fitness Costs of Tigecycline Resistance in <i>Acinetobacter baumannii</i> and the Resistance Mechanism Revealed by a Transposon Mutation Library.","description":"<i>Acinetobacter baumannii</i> is one of the main pathogens causing nosocomial and community-acquired infections. Tigecycline is an important antibiotic for the treatment of multidrug-resistant <i>A. baumannii</i> infections, but strains resistant to tigecycline have also emerged. There are still many unclear questions concerning the mechanism of tigecycline resistance in <i>A. baumannii</i>. In this study, tigecycline-susceptible and tigecycline-intermediate strains were gradually cultured with sub-minimum inhibitory concentrations of tigecycline to select for tigecycline-resistant mutants, and a tigecycline-resistant strain was cultured under 42 °C to select for tigecycline-susceptible mutants. We found that the acquisition of tigecycline resistance affected the susceptibility of the str","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-04-19T12:03:30.079Z","creation":"2025-04-19T12:03:30.079Z"},"accession":"S-EPMC9598136","cross_references":{"pubmed":["36290038"],"doi":["10.3390/antibiotics11101379"]}}