biostudies-literatureBlank-Landeshammer BChristian Doppler Research AssociationAustrian Research Promotion Agency1917https://www.ebi.ac.uk/biostudies/studies/S-EPMC9598320biostudies-literatureUnknown11(10)Intestinal absorption is intrinsically low for lipophilic micronutrients and phytochemicals. Plant extracts acting as bioavailability enhancers can complement for this deficiency by modulation of both, physicochemical and biochemical parameters, in the absorption process. However, these interactions often are limited to specific conditions and the mechanisms and potential synergisms are poorly understood. In this work, we used a human intestinal cell line to characterize the impact of extracts from <i>C. longa</i> (curcuma), <i>Z. officinale</i> (ginger) and <i>P.nigrum</i> (black pepper) on uptake and transport rates of the xanthophylls lutein and zeaxanthin as well as soy isoflavones measured by HPLC-DAD. We found a significant increase in the uptake of lutein in the presence of curcuma Antioxidants (Basel, Switzerland)Improved Bioavailability and Bioaccessibility of Lutein and Isoflavones in Cultured Cells In Vitro through Interaction with Ginger, Curcuma and Black Pepper Extracts.PMC9598320Josef Ressel Center for Phytogenic Drug Research881882Klanert GWeghuber JBlank-Landeshammer BNusser NKonig AMitter LTurisser SIken MfalseImproved Bioavailability and Bioaccessibility of Lutein and Isoflavones in Cultured Cells In Vitro through Interaction with Ginger, Curcuma and Black Pepper Extracts.Intestinal absorption is intrinsically low for lipophilic micronutrients and phytochemicals. Plant extracts acting as bioavailability enhancers can complement for this deficiency by modulation of both, physicochemical and biochemical parameters, in the absorption process. However, these interactions often are limited to specific conditions and the mechanisms and potential synergisms are poorly understood. In this work, we used a human intestinal cell line to characterize the impact of extracts from <i>C. longa</i> (curcuma), <i>Z. officinale</i> (ginger) and <i>P.nigrum</i> (black pepper) on uptake and transport rates of the xanthophylls lutein and zeaxanthin as well as soy isoflavones measured by HPLC-DAD. We found a significant increase in the uptake of lutein in the presence of curcuma 2022-01-01T00:00:00Z2022 Sep2025-04-19T12:07:28.471Z2025-04-19T12:07:28.471ZS-EPMC95983203629064110.3390/antiox11101917