{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11(10)"],"submitter":["Pignatelli P"],"pubmed_abstract":["Sodium-glucose co-transporter-2 inhibitors or gliflozins, the newest anti-hyperglycemic class, induce cardioprotective benefits in patients with type 2 diabetes (T2D). As platelet activation and oxidative stress play a key role in atherothrombotic-related complications, we hypothesized that gliflozins might modulate oxidative stress, platelet activation and thrombus formation. We performed an interventional open-label single-arm before-after study in 32 T2D patients on top of their ongoing metformin therapy. The population was divided into two groups: treatment with GLP-1 receptor agonists (GLP-1RA, Group A) and gliflozins (Group B). Oxidative stress, platelet activation and thrombus growth were assessed before and after 15 days of treatment. Compared to the baseline, gliflozins treatment "],"journal":["Antioxidants (Basel, Switzerland)"],"pagination":["1878"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9598474"],"repository":["biostudies-literature"],"pubmed_title":["The Sodium-Glucose Co-Transporter-2 (SGLT2) Inhibitors Reduce Platelet Activation and Thrombus Formation by Lowering NOX2-Related Oxidative Stress: A Pilot Study."],"pmcid":["PMC9598474"],"pubmed_authors":["D'Amico A","Baratta F","D'Onofrio L","Carnevale R","Buzzetti R","Cammisotto V","Violi F","Chiariello GA","Pignatelli P","Pingitore A","Del Ben M","Maddaloni E","Siena A","Santilli F","Bartimoccia S","Cocomello N","Pastori D","Castellani V"],"additional_accession":[]},"is_claimable":false,"name":"The Sodium-Glucose Co-Transporter-2 (SGLT2) Inhibitors Reduce Platelet Activation and Thrombus Formation by Lowering NOX2-Related Oxidative Stress: A Pilot Study.","description":"Sodium-glucose co-transporter-2 inhibitors or gliflozins, the newest anti-hyperglycemic class, induce cardioprotective benefits in patients with type 2 diabetes (T2D). As platelet activation and oxidative stress play a key role in atherothrombotic-related complications, we hypothesized that gliflozins might modulate oxidative stress, platelet activation and thrombus formation. We performed an interventional open-label single-arm before-after study in 32 T2D patients on top of their ongoing metformin therapy. The population was divided into two groups: treatment with GLP-1 receptor agonists (GLP-1RA, Group A) and gliflozins (Group B). Oxidative stress, platelet activation and thrombus growth were assessed before and after 15 days of treatment. Compared to the baseline, gliflozins treatment ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2025-04-19T12:04:19.286Z","creation":"2025-04-19T12:04:19.286Z"},"accession":"S-EPMC9598474","cross_references":{"pubmed":["36290601"],"doi":["10.3390/antiox11101878"]}}