{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(41)"],"submitter":["Cherif SE"],"pubmed_abstract":["Olefin cross-metathesis is a cornerstone reaction in organic synthesis where stereoselectivity is typically governed by the structure of the catalyst. In this work, we show that merging Grubbs second generation catalyst, a classical <i>E</i>-selective catalyst, with a readily available photocatalyst, enables the exclusive formation of the contra-thermodynamic <i>Z</i>-isomer. The scope and limitations of this unprecedented approach are discussed based on both computational and experimental mechanistic data."],"journal":["Chemical science"],"pagination":["12065-12070"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9600307"],"repository":["biostudies-literature"],"pubmed_title":["Merging Grubbs second-generation catalyst with photocatalysis enables <i>Z</i>-selective metathesis of olefins: scope, limitations, and mechanism."],"pmcid":["PMC9600307"],"pubmed_authors":["Ghosh A","Dixon IM","Lakhdar S","Cherif SE","Chelli S","Kraiem J"],"additional_accession":[]},"is_claimable":false,"name":"Merging Grubbs second-generation catalyst with photocatalysis enables <i>Z</i>-selective metathesis of olefins: scope, limitations, and mechanism.","description":"Olefin cross-metathesis is a cornerstone reaction in organic synthesis where stereoselectivity is typically governed by the structure of the catalyst. In this work, we show that merging Grubbs second generation catalyst, a classical <i>E</i>-selective catalyst, with a readily available photocatalyst, enables the exclusive formation of the contra-thermodynamic <i>Z</i>-isomer. The scope and limitations of this unprecedented approach are discussed based on both computational and experimental mechanistic data.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-04-22T21:12:40.039Z","creation":"2025-04-06T03:30:10.631Z"},"accession":"S-EPMC9600307","cross_references":{"pubmed":["36349104"],"doi":["10.1039/d2sc03961c"]}}