biostudies-literatureUnknown12(10)Jambi LKHelicobacter pylori (H. pylori) continues to be a major health problem worldwide, causing considerable morbidity and mortality due to peptic ulcer disease and gastric cancer. The aim of the present systematic review and meta-analysis was to determine the sensitivity and specificity of 13C/14C-urea breath tests in the diagnosis of H. pylori infection. A PRISMA systematic search appraisal and meta-analysis were conducted. A systematic literature search of PubMed, Web of Science, EMBASE, Scopus, and Google Scholar was conducted up to August 2022. Generic, methodological and statistical data were extracted from the eligible studies, which reported the sensitivity and specificity of 13C/14C-urea breath tests in the diagnosis of H. pylori infection. A random effect meta-analysis was conducted onDiagnostics (Basel, Switzerland)2428https://www.ebi.ac.uk/biostudies/studies/S-EPMC9600925biostudies-literatureSystematic Review and Meta-Analysis on the Sensitivity and Specificity of ¹³C/¹⁴C-Urea Breath Tests in the Diagnosis of <i>Helicobacter pylori</i> Infection.PMC9600925Jambi LKfalseSystematic Review and Meta-Analysis on the Sensitivity and Specificity of ¹³C/¹⁴C-Urea Breath Tests in the Diagnosis of <i>Helicobacter pylori</i> Infection.Helicobacter pylori (H. pylori) continues to be a major health problem worldwide, causing considerable morbidity and mortality due to peptic ulcer disease and gastric cancer. The aim of the present systematic review and meta-analysis was to determine the sensitivity and specificity of 13C/14C-urea breath tests in the diagnosis of H. pylori infection. A PRISMA systematic search appraisal and meta-analysis were conducted. A systematic literature search of PubMed, Web of Science, EMBASE, Scopus, and Google Scholar was conducted up to August 2022. Generic, methodological and statistical data were extracted from the eligible studies, which reported the sensitivity and specificity of 13C/14C-urea breath tests in the diagnosis of H. pylori infection. A random effect meta-analysis was conducted on2022-01-01T00:00:00Z2022 Oct2026-04-07T13:21:56.685Z2025-04-07T09:17:44.967ZS-EPMC96009253629211710.3390/diagnostics12102428