{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11(20)"],"submitter":["Cai X"],"funding":["Zhejiang Provincial Natural Science Foundation of China","National Natural Science Foundation of China","Zhejiang Pharmaceutical Society Hospital Pharmacy Special Research Project","Medical Science and Technology Plan Project of Zhejiang Province","Public Welfare Technology Research Project of Zhejiang Province","Joint Funds of Zhejiang Provincial Natural Science Foundation of China"],"pubmed_abstract":["Signaling via the OX40/OX40L axis plays a key role in CD4+ T cell development, and OX40L expression is primarily restricted to antigen-presenting cells (APCs). This study was designed to assess the role of APC-mediated OX40L expression in the context of the development of rheumatoid arthritis (RA)-associated CD4+ T cell subsets. For these analyses, clinical samples were harvested from patients with osteoarthritis and RA, with additional analyses performed using OX40−/− mice and mice harboring monocyte/macrophage-specific deletions of OX40L. Together, these analyses revealed tissue-specific roles for OX40/OX40L signaling in RA. Specifically, higher levels of synovial macrophage OX40L expression were associated with the enhanced development of T follicular helper cells in the joint microenvi"],"journal":["Cells"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9601235"],"repository":["biostudies-literature"],"pubmed_title":["Synovial Macrophages Expression of OX40L Is Required for Follicular Helper T Cells Differentiation in the Joint Microenvironment"],"pmcid":["PMC9601235"],"funding_grant_id":["LGF21H160023","LYY22H310008","2022485250","2021ZYY12","82003761","LQ22H040005"],"pubmed_authors":["Ren F","Yao Y","Zhang X","Fei W","Zhang M","Cai X","Zhao Y","Lin N"],"additional_accession":[]},"is_claimable":false,"name":"Synovial Macrophages Expression of OX40L Is Required for Follicular Helper T Cells Differentiation in the Joint Microenvironment","description":"Signaling via the OX40/OX40L axis plays a key role in CD4+ T cell development, and OX40L expression is primarily restricted to antigen-presenting cells (APCs). This study was designed to assess the role of APC-mediated OX40L expression in the context of the development of rheumatoid arthritis (RA)-associated CD4+ T cell subsets. For these analyses, clinical samples were harvested from patients with osteoarthritis and RA, with additional analyses performed using OX40−/− mice and mice harboring monocyte/macrophage-specific deletions of OX40L. Together, these analyses revealed tissue-specific roles for OX40/OX40L signaling in RA. Specifically, higher levels of synovial macrophage OX40L expression were associated with the enhanced development of T follicular helper cells in the joint microenvi","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-05-18T11:13:06.321Z","creation":"2025-05-18T11:13:06.321Z"},"accession":"S-EPMC9601235","cross_references":{}}