biostudies-literatureUnknown11(20)Cai XZhejiang Provincial Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaZhejiang Pharmaceutical Society Hospital Pharmacy Special Research ProjectMedical Science and Technology Plan Project of Zhejiang ProvincePublic Welfare Technology Research Project of Zhejiang ProvinceJoint Funds of Zhejiang Provincial Natural Science Foundation of ChinaSignaling via the OX40/OX40L axis plays a key role in CD4+ T cell development, and OX40L expression is primarily restricted to antigen-presenting cells (APCs). This study was designed to assess the role of APC-mediated OX40L expression in the context of the development of rheumatoid arthritis (RA)-associated CD4+ T cell subsets. For these analyses, clinical samples were harvested from patients with osteoarthritis and RA, with additional analyses performed using OX40−/− mice and mice harboring monocyte/macrophage-specific deletions of OX40L. Together, these analyses revealed tissue-specific roles for OX40/OX40L signaling in RA. Specifically, higher levels of synovial macrophage OX40L expression were associated with the enhanced development of T follicular helper cells in the joint microenviCellshttps://www.ebi.ac.uk/biostudies/studies/S-EPMC9601235biostudies-literatureSynovial Macrophages Expression of OX40L Is Required for Follicular Helper T Cells Differentiation in the Joint MicroenvironmentPMC9601235LGF21H160023LYY22H31000820224852502021ZYY1282003761LQ22H040005Ren FYao YZhang XFei WZhang MCai XZhao YLin NfalseSynovial Macrophages Expression of OX40L Is Required for Follicular Helper T Cells Differentiation in the Joint MicroenvironmentSignaling via the OX40/OX40L axis plays a key role in CD4+ T cell development, and OX40L expression is primarily restricted to antigen-presenting cells (APCs). This study was designed to assess the role of APC-mediated OX40L expression in the context of the development of rheumatoid arthritis (RA)-associated CD4+ T cell subsets. For these analyses, clinical samples were harvested from patients with osteoarthritis and RA, with additional analyses performed using OX40−/− mice and mice harboring monocyte/macrophage-specific deletions of OX40L. Together, these analyses revealed tissue-specific roles for OX40/OX40L signaling in RA. Specifically, higher levels of synovial macrophage OX40L expression were associated with the enhanced development of T follicular helper cells in the joint microenvi2022-01-01T00:00:00Z2022 Oct2025-05-18T11:13:06.321Z2025-05-18T11:13:06.321ZS-EPMC9601235