biostudies-literatureDeharo PFrench Government and managed by the National Research Agency6117https://www.ebi.ac.uk/biostudies/studies/S-EPMC9604905biostudies-literatureUnknown11(20)<h4>Background</h4>Transcatheter aortic valve implantation (TAVI) is the preferred treatment for symptomatic severe aortic stenosis (AS) in a majority of patients across all surgical risks.<h4>Patients and methods</h4>Paravalvular leak (PVL) and patient-prosthesis mismatch (PPM) are two frequent complications of TAVI. Therefore, based on the large France-TAVI registry, we planned to report the incidence of both complications following TAVI, evaluate their respective risk factors, and study their respective impacts on long-term clinical outcomes, including mortality.<h4>Results</h4>We identified 47,494 patients in the database who underwent a TAVI in France between 1 January 2010 and 31 December 2019. Within this population, 17,742 patients had information regarding PPM status (5138 with moJournal of clinical medicineLong-Term Prognosis Value of Paravalvular Leak and Patient-Prosthesis Mismatch following Transcatheter Aortic Valve Implantation: Insight from the France-TAVI Registry.PMC9604905ANR-16-RHUS-0003Jaussaud Ndu Chayla FDumonteil NCommeau PMorera PIung BFerrara JPorto ACuisset TGlatt NGouysse MModine TVaillier AEltchaninoff HGariboldi VVerhoye JPDeharo PLeroux LGilard MBenamer HBeurtheret SCayla GLefevre TCollet JPCollart FLe Breton HTheron AFrance-TAVI and STOP-AS InvestigatorsfalseLong-Term Prognosis Value of Paravalvular Leak and Patient-Prosthesis Mismatch following Transcatheter Aortic Valve Implantation: Insight from the France-TAVI Registry.<h4>Background</h4>Transcatheter aortic valve implantation (TAVI) is the preferred treatment for symptomatic severe aortic stenosis (AS) in a majority of patients across all surgical risks.<h4>Patients and methods</h4>Paravalvular leak (PVL) and patient-prosthesis mismatch (PPM) are two frequent complications of TAVI. Therefore, based on the large France-TAVI registry, we planned to report the incidence of both complications following TAVI, evaluate their respective risk factors, and study their respective impacts on long-term clinical outcomes, including mortality.<h4>Results</h4>We identified 47,494 patients in the database who underwent a TAVI in France between 1 January 2010 and 31 December 2019. Within this population, 17,742 patients had information regarding PPM status (5138 with mo2022-01-01T00:00:00Z2022 Oct2025-04-19T12:06:48.279Z2025-04-19T12:06:48.279ZS-EPMC96049053629443810.3390/jcm11206117