{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hu X"],"funding":["the 2017 Chinese Nutrition Society (CNS) Nutrition Research Foundation-DSM Research Fund","the Basic Scientific Research Program of Wenzhou Medical University, China","National Natural Science Foundation of China","Tseng-Lien Lin Foundation, Taiwan, and Katsuzo and Kiyo Aoshima Memorial Funds, Japan","China Medical University Hospital, Academia Sinica Stroke Biosignature Project","the Ministry of Health and Welfare, Taiwan","MOST Clinical Trial Consortium for Stroke","The PhD Programs Foundation of Wenzhou Medical University, China"],"pagination":["1645"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9605069"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(10)"],"pubmed_abstract":["We aimed to investigate the association between either or both of benzodiazepines (BZDs) and non-BZDs and the incidence of atrial fibrillation (AF) in the Taiwan National Health Insurance Database. The participants with at least two prescriptions of BZDs and/or non-BZDs were identified as hypnotics users, whereas those without any prescription of hypnotics were non-hypnotics users. The hypnotics and non-hypnotics cohorts were 1:1 matched on their propensity scores. A total of 109,704 AF-free individuals were included; 610 AF cases occurred in the 54,852 hypnotics users and 166 in the 54,852 non-hypnotics users during the 602,470 person-years of follow-up, with a higher risk of new-onset AF in the users than the non-users (hazard ratio (HR): 3.61, 95% confidence interval [CI]: 3.04-4.28). The users at the highest tertiles of the estimated defined daily doses per one year (DDD) had a greater risk for AF than the non-users, with the risk increasing by 7.13-fold (95% CI: 5.86-8.67) for >0.74-DDD BZDs, 10.68-fold (95% CI: 6.13-18.62) for >4.72-DDD non-BZDs, and 3.26-fold (95% CI: 2.38-4.47) for > 1.65-DDD combinations of BZDs with non-BZDs, respectively. In conclusion, hypnotics use was associated with elevated incidence of AF in the Taiwanese population, which highlighted that the high-dose usage of hypnotics needs more caution in clinical cardiological practice."],"journal":["Journal of personalized medicine"],"pubmed_title":["Hypnotics Use Is Associated with Elevated Incident Atrial Fibrillation: A Propensity-Score Matched Analysis of Cohort Study."],"pmcid":["PMC9605069"],"funding_grant_id":["2017-008","the CMU107-Z-03 & CMU 109-S-55 from China Medical University","MOST 108-2321-B-039-004","81900737","MOHW108-TDU-B-212-133004","89217015","KYYW202015","BM10701010021"],"pubmed_authors":["Zhang XH","Adeniran E","Lin JJ","Liu YL","Hu X","Chen HY","Yang B","Gong SQ","Jong GP","Wang L","Lin MC"],"additional_accession":[]},"is_claimable":false,"name":"Hypnotics Use Is Associated with Elevated Incident Atrial Fibrillation: A Propensity-Score Matched Analysis of Cohort Study.","description":"We aimed to investigate the association between either or both of benzodiazepines (BZDs) and non-BZDs and the incidence of atrial fibrillation (AF) in the Taiwan National Health Insurance Database. The participants with at least two prescriptions of BZDs and/or non-BZDs were identified as hypnotics users, whereas those without any prescription of hypnotics were non-hypnotics users. The hypnotics and non-hypnotics cohorts were 1:1 matched on their propensity scores. A total of 109,704 AF-free individuals were included; 610 AF cases occurred in the 54,852 hypnotics users and 166 in the 54,852 non-hypnotics users during the 602,470 person-years of follow-up, with a higher risk of new-onset AF in the users than the non-users (hazard ratio (HR): 3.61, 95% confidence interval [CI]: 3.04-4.28). The users at the highest tertiles of the estimated defined daily doses per one year (DDD) had a greater risk for AF than the non-users, with the risk increasing by 7.13-fold (95% CI: 5.86-8.67) for >0.74-DDD BZDs, 10.68-fold (95% CI: 6.13-18.62) for >4.72-DDD non-BZDs, and 3.26-fold (95% CI: 2.38-4.47) for > 1.65-DDD combinations of BZDs with non-BZDs, respectively. In conclusion, hypnotics use was associated with elevated incidence of AF in the Taiwanese population, which highlighted that the high-dose usage of hypnotics needs more caution in clinical cardiological practice.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-04-18T21:22:31.664Z","creation":"2025-04-07T09:16:12.504Z"},"accession":"S-EPMC9605069","cross_references":{"pubmed":["36294784"],"doi":["10.3390/jpm12101645"]}}