biostudies-literatureSilva SDCoordenção de Aperfeiçoamento de Pessoal de Nível SuperiorNational Council for Scientific and Technological DevelopmentCoordination for the Qualification of Higher Level Staff1492https://www.ebi.ac.uk/biostudies/studies/S-EPMC9605075biostudies-literatureUnknown12(10)Multidrug-resistant bacteria are of critical importance and a problem for human health and food preservation; the discovery of new antimicrobial substances to control their proliferation is part of the solution. This work reports on 57 antagonistic <i>Aeromonas</i> strains, of which 38 strains were antagonistic towards problematic human pathogens. The genome of the most antagonistic strain was sequenced and identified as <i>Aeromonas allosaccharophila</i>. Its genome was fully annotated and mined for genes that might explain that activity. Strain AE59-TE was antagonistic toward clinically relevant gram-negative and gram-positive multidrug-resistant bacteria, including <i>Klebsiella pneumoniae</i> KPC, <i>Escherichia coli</i> ESBL, <i>Salmonella typhimurium</i>, and <i>Staphylococcus aureusLife (Basel, Switzerland)<i>Aeromonas allosaccharophila</i> Strain AE59-TE2 Is Highly Antagonistic towards Multidrug-Resistant Human Pathogens, What Does Its Genome Tell Us?PMC96050750000141225/2018-1Thompson FLMacrae AOliveira SSSilva SDRibeiro JRARamos RTJSouza YPAFreitas-Almeida ACWhiteley ASGuedes FAFAmaral JRVfalse<i>Aeromonas allosaccharophila</i> Strain AE59-TE2 Is Highly Antagonistic towards Multidrug-Resistant Human Pathogens, What Does Its Genome Tell Us?Multidrug-resistant bacteria are of critical importance and a problem for human health and food preservation; the discovery of new antimicrobial substances to control their proliferation is part of the solution. This work reports on 57 antagonistic <i>Aeromonas</i> strains, of which 38 strains were antagonistic towards problematic human pathogens. The genome of the most antagonistic strain was sequenced and identified as <i>Aeromonas allosaccharophila</i>. Its genome was fully annotated and mined for genes that might explain that activity. Strain AE59-TE was antagonistic toward clinically relevant gram-negative and gram-positive multidrug-resistant bacteria, including <i>Klebsiella pneumoniae</i> KPC, <i>Escherichia coli</i> ESBL, <i>Salmonella typhimurium</i>, and <i>Staphylococcus aureus2022-01-01T00:00:00Z2022 Sep2026-04-08T11:47:40.729Z2025-04-04T08:54:43.912ZS-EPMC96050753629492610.3390/life12101492